Research in Dr. Safe's Laboratory is primarily focused on the molecular biology of hormone/growth factor-induced gene expression in breast cancer cells, the development of new mechanism-based drugs for treatment of breast and other cancers and the differential activation of estrogen receptor a (ERa) and ERb by endocrine disruptors. 

Dr. Lee’s research is primarily focused on the molecular biology of NR4A orphan nuclear receptors in cancer cells and the development of new mechanism-based drugs targeting NR4As for treatment of pancreatic, lung and other cancers.