Durga Nand Tripathi

Durga Nand Tripathi

Postdoctoral Research Associate

Institute of Biosciences and Technology
2121 W. Holcombe Blvd
Houston, TX   77030

Phone: 713-677-7444

Education and Training

U.T. M.D. Anderson Cancer Center, Smithville, Texas, USA,
Postdoctoral Fellow, 2011

National Institute of Pharmaceutical Education and Research, SAS Nagar, India
Ph.D., Pharmacology & Toxicology, 2010

National Institute of Pharmaceutical Education and Research, SAS Nagar, India
M.S., Pharmacology & Toxicology, 2006

Kumaun University, Nainital, India,
B. Pharmacy, 2004

Recent Publications

  • Zhang J*, Tripathi DN*, Jing J*, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature Cell Biology 2015 Sep 7. doi: 10.1038/ncb3230 (In Press). * equal contribution
  • Liu XD, Yao J, Tripathi DN, Ding Z, Xu Y, Sun M, Zhang J, Bai S, German P, Hoang A, Zhou L, Jonasch D, Zhang X, Conti CJ, Efstathiou E, Tannir NM, Eissa NT, Mills GB, Walker CL, Jonasch E. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene. 34 (2015) 2450-2460.
  • Tripathi DN, Chowdhury R, Trudel LJ, Tee AR, Slack RS, Walker CL, Wogan GN. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci U S A. 110 (2013) E2950-E2957.
  • Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Nardo AD, Han JM, Kwiatkowski E, Dunlop EA, Dodd KM, Folkerth RD, Faust PL, Kastan MB, Sahin M, Walker CL. A TSC signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nature Cell Biology. 15 (2013) 1186-1196.
  • Mondal SC, Tripathi DN, Vikram A, Ramarao P, Jena GB. Furosemide-induced genotoxicity and cytotoxicity in the hepatocytes, but weak genotoxicity in the bone marrow cells of mice. Fundamental and Clinical Pharmacology 26 (2012) 383-392.
  • Trivedi PP, Tripathi DN and Jena GB. Hesperetin protects testicular toxicity of doxorubicin in rat: Role of NFκB, p38 and caspase-3, Food and Chemical Toxicology, 49 (2011) 838-47.
  • Gupta C, Tripathi DN, Vikram A, Ramarao P and Jena GB. Quercetin inhibits diethylnitrosamine induced hepatic pre-neoplastic lesions in rat. Nutrition and Cancer: An International Journal 63 (2011) 234-41.
  • Trivedi PP, Kushwaha S, Tripathi DN, Jena GB. Cardioprotective Effects of Hesperetin against Doxorubicin-Induced Oxidative Stress and DNA Damage in Rat. Cardiovasc Toxicology 11 (2011) 215-225.
  • TripathiDN, and  Jena GB. Effect of melatonin on the expression of Nrf2  and NF-κB during cyclophosphamide-induced urinary bladder injury in rat. Journal of Pineal Research 48 (2010) 324-331.
  • Tripathi DN, and  Jena GB. Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: Role of Nrf2, p53, p38 and phase-II enzymes. Mutation Research 696 (2010) 69-80.
  • Trivedi PP, Kushwaha S, Tripathi DN and Jena GB. Evaluation of male germ cell toxicity in rats: Correlation between sperm head morphology and sperm comet assay. Mutation Research 703 (2010) 115-121.
  • Kushwaha S, Tripathi DN, Vikram A, Ramarao P and Jena GB. Evaluation of multi-organ DNA damage by comet assay from 28 days repeated dose oral toxicity test in mice: A practical approach for test integration in regulatory toxicity testing. Regulatory Toxicolgy and Pharmacology 58 (2010) 145-154.
  • Dadhania VP, Tripathi DN, Vikram A, Ramarao P and  Jena GB. Intervention of α- lipoic acid ameliorates methotrexate induced oxidative stress and genotoxicity: A study in rat  intestine. Chemico-biological Interaction 183 (2010) 85-97.
  • Gupta C, Vikram A, Tripathi DN, Ramarao P and Jena GB. Antioxidant and antimutagenic effect of quercetin against DEN induced hepatotoxcity in rat. Phytotherapy Research 24 (2010) 119-128.
  • Tripathi DN, and  Jena GB. Intervention of astaxanthin against cyclophosphamide-induced   oxidative   stress   and   DNA   damage:   A   study   in   mice.   Chemico-biological Interaction 180 (2009) 398-406.
  • Pawar AA,  Vikram A,  Tripathi DN,  Padmanabhan S,  Ramarao P,  Jena GB. Modulation  of  Mitomycin  C  Induced  Genotoxicity  by  Acetyl- and Thio- Analogue of Salicylic acid. In Vivo, 23 (2009) 303-307.
  • Saandeep K, Vikram A, Tripathi DN, Ramarao P, Jena GB. Influence of hyperglycemia on chemical induced toxicity: Study with cyclophosphamide in rat. Basic and Clinical Pharmacology and Toxicology 105 (2009) 236-242.
  • Tripathi DN, and  Jena GB. Ebselen attenuates cyclophosphamide-induced  oxidative stress and DNA damage in mice. Free Radical Research 42 (2008) 966-977.
  • Tripathi DN, and  Jena GB. Astaxanthin Inhibits Cytotoxic and Genotoxic Effects of Cyclophosphamide in Mice Germ Cells. Toxicology, 248 (2008) 96–103.
  • Tripathi DN, Pawar AA, Vikram A, Ramarao P, Jena GB. Use of the Alkaline Comet Assay for the Detection of Trans-placental Genotoxins in Newborn Mice. Mutation Research 653 (2008) 134–139.
  • Padmanabhan S, Tripathi DN, Vikram A, Ramarao P, Jena GB. Cytotoxic and Genotoxic Effects of Methotrexate in Germ Cells of Male Swiss Mice, Mutation Research, 655 (2008) 59-67. 
  • Padmanabhan S, Tripathi DN, Vikram A, Ramarao P, Jena GB. Methotrexate-induced cytotoxicity  and  genotoxicity  in  germ  cells  of  mice:  Intervention  of  folic  and  folinic  acid, Mutation Research, 673 (2008) 43-52.
  • Vikram A, Tripathi DN, Pawar AA, Ramarao P, Jena GB. Pre-bled-young-rats in genotoxicity testing: A model for peripheral blood micronucleus assay. Regulatory Toxicology and Pharmacology, 52 (2008) 147-157.
  • Vikram A, Tripathi DN, Ramarao P, Jena GB. Intervention of D-glucose ameliorates the toxicity  of  streptozotocin  in  accessory  sex  organs  of  rat,  Toxicology  and  Applied Pharmacology 226 (2008) 84–93.
  • Tikoo K, Tripathi DN, Kabra DG, Sharma V, Gaikwad AB. Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53, FEBS Letters 581 (2007) 1071–1078.
  • Vikram A, Tripathi DN, Ramarao P, Jena GB, Evaluation of streptozotocin genotoxicity in  rats  from  different  ages  using  the  micronucleus  assay,  Regulatory  Toxicology  and Pharmacology 49 (2007) 238–244.
  • Pawar AA, Tripathi DN, Ramarao P and Jena GB. Protective Effects of American ginseng (Panax quinquefolium) against Mitomycin C induced Micronuclei in Mice, Phytotherapy Research 21 (2007) 1221–1227.