Our laboratory studies how cells receive and process information from their chemical and physical environments under normal and disease conditions. In particular, our research interests focus on understanding the biochemical properties and cellular functions of GTP-binding proteins (small and heterotrimeric), their receptors and signaling pathways in cell growth, proliferation, and differentiation. Our current projects include: 1) G-protein coupled receptors and signaling pathways in cell growth and differentiation; 2) Biochemical properties and cellular functions of GTP-binding proteins, their regulators and effectors in normal and human disease conditions; 3) Molecular mechanisms of human stem cell differentiation. A multi-faceted approach (biochemistry, cell and molecular biology, genetics, and mouse models) is taken in our studies, with the ultimate goal of understanding the regulation of cell growth, differentiation, and proliferation.