Five Most Significant Publications Prior to 2012

McKeehan WL (1982) Glycolysis, glutaminolysis and cell proliferation.  Cell Biol Int Rep. 1982 Jul;6(7):635-50. PMID: 6751566

Kan, M., F. Wang, J. Xu, E. Shi, J.W. Crabb, J. Hou, and W.L. McKeehan (1993) An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science 259:1918-1921.

Hou J, Wang F, McKeehan WL (1994) Molecular cloning and expression of the gene for a major leucine-rich protein from human hepatoblastoma cells (HepG2). In Vitro Cell Dev Biol Anim. 1994 Feb;30A(2):111-4.  PMID: 8012652

Yu, C., F. Wang, M. Kan, C. Jin, R.B. Jones, M. Weinstein, C. Deng, and W.L. McKeehan (2000) Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J. Biol. Chem. 275: 15482-15489.

Liu, L., Xie, R., Yang, C. and McKeehan, W.L. (2009) Dual function microtubule- and mitochondria-associated proteins mediate mitotic cell death. Cellular Oncol. 31:393-405.

Publications 2012

Wang, F., McKeehan, W.L., Shen, M.M., and Abate-Shen, C. (2012) Genetically Engineered Mouse Models in Prostate Cancer Research. In: D. J. Tindall & P.T. Scardino, eds. Recent Advances in Prostate Cancer: Basic Science Discoveries and Clinical Advances, pp 219-282, World Scientific eBooks

Zhang J, Liu J, Huang Y, Chang J, Liu L, McKeehan WL, Martin JF, Wang F. FRS2a-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity Circulation Research 2012, 110(4):e29-39. PMID: 22207710.

Zhang J, Liu J, Liu L, McKeehan WL, Wang F. The fibroblast growth factor signaling axis controls cardiac stem cells differentiation through autophagy regulation. Autophagy 2012, 8(4). PMID: 22302007

Liu L, McKeehan WL, Wang F, Xie R. MAP1S enhances autophagy to suppress tumorigenesis. (2012) Autophagy 8(2): 278-280. PMID: 22301994.

Yang X, Li Q, Lin X, Ma Y, Yue X, Tao Z, Wang F, McKeehan WL, Wei L, Schwartz RJ, Chang J. (2012) Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1. FASEB J. 26(5):2105-16 [EPub 2012 Jan 25] PMID: 22278938

Zhang J, Liu J, Liu L, McKeehan WL, Wang F. The fibroblast growth factor signaling axis controls cardiac stem cell differentiation through regulating autophagy. Autophagy 8(4) [Epub 2012 Apr 1] PMID: 22302007

Yang C, Jin C, Wang F, McKeehan WL, Luo Y. (2012) Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.  PLoS ONE 7(3):e33870 [EPub 2012 Mar 19] PMID: 22442730

Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P. (2012) Novel role of NOX in supporting aerobic gycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy.  PLoS Biol. 10(5):e1001326. [Epub 2012 May 8] PMID: 22589701

McKeehan WL.  A tribute to Richard G. Ham (1932-2011).  (2012) In Vitro Cell Dev Biol Anim. 48(5): 259-270 [Epub 2012 May 12] PMID: 22580908

Dong W, Lu W, McKeehan WL, Luo Y, Ye S (2012) Structural basic of heparan sulfate-specific degradation by heparinase III. Protein Cell 3(12):950-61 [Epub 2012 July 21]

Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL, Yang C, McKeehan WL, Wechsler-Reya RJ (2012) Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. (2013) Oncogene 32(35):4181-8. doi: 10.1038/onc.2012.440. [Epub 2012 Oct 8] PMID: 23045271

Yang C, Wang C, Ye M, Jin C, He W, Wang F, McKeehan WL, Luo Y.  (2012) Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress.  Nutr Metab (Lond). 9(1):94 [Epub 2012 Oct 30]
Foltz IN, Hu S, King C, Wu X, Yang C, Wang W, Weiszmann J, Stevens J, Chen JS, Nuanmanee N, Gupte J, Komorowski R, Sekirov L, Hager T, Arora T, Ge H, Baribault H, Wang F, Sheng J, Karow JM, Wang M, Luo Y, McKeehan W, Wang Z, Véniant MM, Li Y. (2012) Treating diabetes and obesity with an FGF21-mimetic antibody activating the ßKlotho/FGFR1c receptor complex.  Sci Transl Med 4(162):162ra153

Publications 2013

Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y. (2013) Activation of liver FGF21 in hepatocarcinogenesis and during hepatic stress.  BMC Gastroenterol.13(1):67. [Epub 17 Apr 2013]

Wang C, Chang JYF, Yang C, Huang Y, Liu J, You P,  McKeehan WL, Wang F, Li X (2013) Type 1 fibroblast growth factor receptor in cranial neural crest cells-derived mesenchyme is required for palatogenesis. J Biol Chem. 2013 Jul 26;288(30):22174-83. doi: 10.1074/jbc.M113.463620 [Epub 2013 Jun 10]  PMID: 23754280

Chang JYF, Wang C, Jin C, Yang C, Huang Y, Liu J, McKeehan WL, D’Souza RN,  Wang F (2013) Self-renewal and multilineage differentiation of mouse dental epithelial stem cells. Stem Cell Res. 2013 Jul 1;11(3):990-1002. doi: 10.1016/j.scr.2013.06.008. [Epub ahead of print] PMID: 23906788

Chang, JYF, Wang C, Jin C, Yang C, Huang Y, Liu J, D’Souza RN, McKeehan WL, Wang F (2013) Fibroblast growth factor signaling is essential for self-renewal of tooth epithelial stem cells. J Biol Chem. 4;288(40):28952-28961 [Epub 2013 Aug 26] PMID: 23979135 

Corn P, Wang F, McKeehan WL, Navone N. (2013) Targeting fibroblast growth factor pathways in prostate cancer. Clin Cancer Res. 2013 Nov 1;19(21):5856-66.  [Epub 2013 Sep 19] PMID: 24052019.

Jung D, York JP, Wang L, Yang C, Zhang A, Francis HL, Webb P, McKeehan WL, Alpini G, Lesage GD, Moore DD, Xia X. (2013) FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway.  Pflugers Arch. [Epub 2013 Sep 26]  PMID: 24068255

Luo Y, Yang C, Ye M, Jin C, Lee MH, Yeung SCJ, McKeehan WL (2013) Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations.  Cancer Metab. 2013 Nov 25;1(1):21.  PMID: 24279986.

Luo Y, McKeehan WL (2013) Stressed liver and muscle call on adipocytes with FGF21. Front. Endocrinol. 4:194. PMID: 24385972

Publications 2014

Wang F, Luo Y and McKeehan WL  (2014) The FGF Signaling Axis in Prostate Tumorigenesis  In:  E. Gelmann, C. Sawyers and F. Rauscher, eds. Molecular Oncology: Causes of Cancer and Targets for Treatment, pp190-203, Cambridge University Press (Academic Press).

Shoji K, Teishima J, Hayashi T, Ohara S, McKeehan WL, Matsubara A.  (2014) Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells. Oncol Rep. 2014 May 20. doi: 10.3892/or.2014.3200. [Epub ahead of print]  PMID: 24839986

Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou P-C, Shin J-H, Choi HH, Chen J-S, Zhao R, Chen J, Gully C, Carlock C, Qi Y, Zhang Y, Wu Y, Esteva FJ, Luo Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Symmans WF, Lee M-H, Yeung S-C J.  Obesity Induces Transcriptomic Changes Enhancing Cancer Hallmarks of Estrogen Receptor-Positive Breast Cancer. (2014) J Natl Cancer Inst (in press).

Phillips, T.D., M. Richardson, L. Chen, L. He, T.J. McDonald, L.H. Cizmas, S.H. Safe,  K.C. Donnelly, F. Wang, B. Moorthy, and G.-D. Zhou (2014) Mechanistic Relationships between Hepatic Genotoxicity and Carcinogenicity in Male B6C3F1 Mice Treated with Polycyclic Aromatic Hydrocarbon Mixtures. Archives of Toxicology (in press)

Wan, X., P. G. Corn, J. Yang, N. Palanisamy, M. W. Starbuck, E. Efstathiou, E. M. L Tapia, A. Zurita, A. Aparicio, M. K. Ravoori, E. S. Vazquez, D. Robinson, Y-M Wu, X. Cao, M. Lyer, W. McKeehan, V. Kundra, F. Wang, P. Troncoso, A. M. Chinnaiyan, C. J. Logothetis, N. M. Navone1 (2014) Prostate cancer cell–bone cell cross-talk via FGFR1 mediates dovitinib antitumor activity in men with bone metastases. Science Translational Medicine (in press).

Wang C., C. Yang, J. YF Chang, Y. Li, C. Jin, Y. Luo, P. You, X. Li, W. L. McKeehan, and F. Wang (2014) Hepatocyte FRS2a is Essential for the Endocrine Fibroblast Growth Factor to Limit the Amplitude of Bile Acid Production Induced by Prandial Activity.  Current Molecular Medicine (in press)

For complete list of publications, please visit: