News

February 2016

American Heart Association Awardees List - Tingli Yang
https://professional.heart.org/idc/groups/ahamah-public/@wcm/@sop/@rsch/documents/downloadable/ucm_432214.pdf

September 2014
American Heart Association Awardees List - Xiangsheng "Sean" Yang
https://my.americanheart.org/idc/groups/ahamah-public/@wcm/@sop/@rsch/documents/downloadable/ucm_432239.pdf

July 2014
Pathways to Cardiovascular Therapeutics Program
-
Xiaojing Yue
http://my.americanheart.org/idc/groups/ahamah-public/@wcm/@sop/@scon/documents/downloadable/ucm_465270.pdf

April 23, 2013
"Institute of Biosciences and Technology researchers make connection between genetic defect and congenital hydrocephalus" http://www.hydroassoc.org/docs/PressReleases/IBTPNASPRESSRELEASE.pdf 

Publications

2016

Yue X, Lin X, Yang T, Yang X, Yi X, Jiang X, Li X, Li T, Guo J, Dai Y, Shi J, Wei L, Youker KA, Torre-Amione G, Yu Y, Andrade KC, Chang J. Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis. Hypertension. 2016; 67(3):597-605. NIHMSID: NIHMS746184 PubMed [journal] PMID: 26781283 PMCID: PMC4752414 

2015

Jie WAndrade KC, Lin XYang XYue XChang JPathophysiological Functions of Rnd3/RhoEComprehensive Physiology. 2015; 6(1):169-86. PubMed [journal]  PMID: 26756630

Liu B, Lin X, Yang X, Dong H, Yue X, Andrade KC, Guo Z, Yang J, Wu L, Zhu X, Zhang S, Tian D, Wang J, Cai Q, Chen Q, Mao S, Chen Q, Chang J.  Downregulation of RND3/RhoE in glioblastoma patients promotes tumorigenesis through augmentation of notch transcriptional complex activity. Cancer Medicine 2015 Jun 24. doi: 10.1002/cam4.484. [Epub ahead of print].  PMID: 26108681. PMCID: PMC4567025

Kim EYZhang YYe BSegura AM, Beketaev IXi YYu WChang JLi FWang JInvolvement of activated SUMO-2 conjugation in cardiomyopathy. Biochim Biophys Acta 2015; 1852(7):1388-99. PubMed [journal] PMID: 25857621

Yang XWang TLin XYue XWang QWang GFu QAi XChiang DYMiyake CYWehrens XHChang JGenetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circulation Research 2015; 116(1):e1-e10. NIHMSID: NIHMS638385. PubMed [journal] PMID: 25348166 PMCID: PMC4282622

Kim EYZhang YBeketaev ISegura AMYu WXi YChang JWang J. SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy Journal of Molecular and Cellular Cardiology 2015; 78:154-64. PubMed [journal] PMID: 25128087

2014

Wang XHuang WLiu GCai WMillard RWWang YChang JPeng TFan GC. Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. Journal of Molecular and Cellular Cardiology 2014; 74:139-50. NIHMSID: NIHMS595036 PubMed [journal] PMID: 24825548 PMCID: PMC4120246


Yue X, Yang X, Lin X, Yang T, Yi X, Dai Y, Guo J, Li T, Shi J, Wei L, Fan G, Chen C, Chang J. Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell Death and Disease. 2014 Jun 5;5:e1284. doi: 10.1038/cddis.2014.235. PubMed PMID: 24901055 PMCID: PMC4611712

Wang XHuang WYang YWang YPeng TChang JCaldwell CCZingarelli BFan GC.  Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis. Biochim Biophys Acta 2014; 1842(5):701-11. NIHMSID: NIHMS561798 PubMed [journal] PMID: 24486439 PMCID: PMC3959587

Surma MHandy CChang JKapur RWei LShi J.  ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment. PloS ONE. 2014; 9(3):e90758. PubMed [journal] PMID: 2 4595357 PMCID: PMC3942480

2013

Lin XLiu BYang XYue XDiao LWang JChang J.  Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling.  Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(20):8236-41.  PubMed [journal] PMID: 23630292 PMCID: PMC3657816

Xi Lin, Baohui Liu, Xiangsheng Yang, Xiaojing Yue and Jiang Chang. Rnd3 deficiency results in aqueductal stenosis contributing to hydrocephalus through upregulation of Notch signalingPro Nat Acad Sci USA, 2013 May 14;110 (20):8236-41. doi: 10.1073/pnas.1219995110. Epub 2013 Apr 29. PubMed PMID: 23630292 PubMed Central PMCID: PMC3657816.

Li Q, Guo J, Lin X, Yang X, Ma Y, Fan GC, Chang J. An intragenic SRF-dependent regulatory motif directs a cardiac-specific microRNA-1-1/133a-2 expressionPloS ONE, 8(9): e75470. doi:10.1371/journal.pone.0075470. Epub 2013 September 13. PubMed PMID: 24058688 PubMed Central PMCID: PMC3772891.

2012

Yang X, Li Q, Lin X, Ma Y, Yue X, Tao Z, Wang F, McKeehan W, Wei L, Schwartz R, Chang J. Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1FASEB Journal. Published online January 25 2012.  PubMed PMID: 22278938 PubMed Central PMCID: PMC3336781

Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J. Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. Journal of Molecular and Cellular Cardiology 2012; 52(3):638-49. NIHMSID: NIHMS342248 PubMed [journal] PMID: 22155005 PMCID: PMC3294171

Wong J, Zhang J, Yanagawa B, Luo Z, Yang X, Chang J, McManus B, Luo H. Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac gene expressionCell Research. Jul. 19.doi:10.1038/cr. 2011.114. [Epub ahead of print] PubMed PMID: 21769134 PubMed Central PMCID: PMC3271589.

Lin X, Yang X, Li Q, Ma Y, Cui S, He D, Lin X, Schwartz RJ, Chang J.  Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway. Molecular and Cellular Biology 2012; 32(2):297-308. PubMed [journal] PMID: 22106411 PMCID: PMC3255775

Zhou CC, Chang J, Mi T, Abbasi S, Gu D, Huang L, Zhang W, Kellems RE, Schwartz RJ, Xia Y.  Targeted expression of Cre recombinase provokes placental-specific DNA recombination in transgenic mice. PloS ONE. 2012; 7(2):e29236. PubMed [journal] PMID: 22363401 PMCID: PMC3281813

Zhang X, Wang X, Zhu H, Kranias EG, Tang Y, Peng T, Chang J, Fan GC.  Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2.  PloS ONE. 2012; 7(3):e32765.  PubMed [journal] PMID: 22427880 PMCID: PMC3299679

Lin X, Yang X, Li Q, Ma Y, Cui S, He D, Lin X, Schwartz R, Chang, J. Protein tyrosine phosphatase‐like A regulates myoblast proliferation and differentiation through MyoG and cell cycling signaling pathwayMolecular and Cellular Biology. 32:297-308; 2012.  PubMed PMID: 22106411 PubMed Central PMCID: PMC3255775.

2011

Zhang LValdez JMZhang BWei LChang JXin L.  ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PloS one. 2011; 6(3):e18271. PubMed [journal] PMID: 21464902 PMCID: PMC3065488

Kim EYChen LMa YYu WChang JMoskowitz IPWang J.  Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects. PloS ONE. 2011; 6(6):e20803. PubMed [journal] PMID: 21677783 PMCID: PMC3108998

2010

Q. Li, X. Lin, X. Yang and Jiang Chang. NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repressionAm J Physiol Heart Circ Physiol 298:H1340-H1347, 2010.  PubMed PMID: 20173049 PubMed Central PMCID: PMC3774484.