Recent Publications

Feng L, Maddox MM, Alam MZ, Tsutsumi LS, Narula G, Bruhn DF, Wu X, Sandhaus S, Lee RB, Simmons CJ, Tse-Dinh YC, Hurdle JG, Lee RE, Sun D.  Synthesis, Structure-Activity Relationship Studies, and Antibacterial Evaluation of 4-Chromanones and Chalcones, as Well as Olympicin A and Derivatives. J Med Chem. 2014 (Ahead of print, Oct 7, PMID: 25238443).

Kumar M, Adhikari S., Hurdle, J.G. (2014) Action of nitroheterocyclic drugs against Clostridium difficile.  Int. J. Antimicrob. Agents 44:314-9.

Cherian, T. P., Wu, X., Maddox, M.M., Singh, A.P., Lee, R.E., Hurdle, J.G. (2014) Chemical modulation of the biological activity of reutericyclin: a membrane-active antibiotic from Lactobacillus reuteri. Sci Rep. 4:4721

Wu X, Hurdle JG. (2014) The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection. Can. J. Microbiol. 60:251-4

Richard E. Lee, Julian G. Hurdle, Jiuyu Liu, Tanja Matt, Michael Scherman, Pavan Vaddady, Zhong Zheng, Jianjun Qi, David Bruhn, Rashid Akbergenov, Sourav Das, Dora B. Madhura, Ashit Trivedi, Maria-Cristina Villellas, Robin. B. Lee, Rakesh, Dianqing Sun, Michael R. McNeil, Jose A. Ainsa, Helena Boshoff, Bernd Meibohm, Erik C. Böttger, Anne J. Lenaerts. (2014) Spectinamides: a new class of semisynthetic anti-tuberculosis agents that overcome native drug efflux.  Nat. Med. 20:152-8. 

Rakesh, Bruhn, D.F., Scherman, M.S., Woolhiser, L.K., Madhura, D.B., Maddox, M.M., Lee, R.B., Hurdle, J.G., McNeil, M.R., Lenaerts, A.J., Meibohm, B. and Lee, R.E. (2014) Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis.  PLoS One. 9:e87909.

Tsutsumi LS, Owusu YB, Hurdle JG, Sun D. Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review. Curr Top Med Chem. 14:152-75.

Wu, X., Alam, X., Feng, L., Tsutsumi, L.S. Sun, D. and Hurdle J.G (2014) Prospects for flavonoid and related phytochemicals as nature-inspired treatments for Clostridium difficile infection. J. Appl. Microbiol. 116: 23-31.

Wu X, Hurdle JG. (2013). Screening for a diamond in the rough. Chem Biol. 20(9):1091-2.

Shen L, Maddox MM, Adhikari S, Bruhn DF, Kumar M, Lee RE, Hurdle JG, Lee RE, Sun D. (2013)Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents. J Antibiot (Tokyo). 66:319-25.

Wu XCherian PTLee REHurdle JG.  (2013). The membrane as a target for controlling hypervirulent Clostridium difficile infections. J Antimicrob Chemother. 68:806-15.

Sun D, Hurdle JG, Lee R, Lee R, Cushman M, Pezzuto JM.  (2012). Evaluation of flavonoid and resveratrol chemical libraries rveals abyssinone II as a promising antibacterial lead. ChemMedChem. 7:1541-5.  

Brown JR, North EJ, Hurdle J.G., Morisseau C, Scarborough JS, Sun D, Korduláková J, Scherman MS, Jones V, Grzegorzewicz A, Crew RM, Jackson M, McNeil MR, Lee RE (). The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem. 9:5585-95Hurdle, J.G., Heathcott, A.E., Yang, L., Yan. B., Lee, R.E. (2011) Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations. J Antimicrob Chemother; 66:1773-6.

Hurdle, J.G., O'Neill, A.J., Chopra, I., Lee, R.E. (2011) Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nat. Rev. Microbiol. 9:62-75.

Hevener, K., Yun, M.K., Qi, J., Kerr, I., Babaoglu, K., Hurdle, J., Balakrishna, K., White, S. and Lee, R.  (2010) Structural studies of pterin-based inhibitors of dihydropteroate synthase. J. Med. Chem. 53:166-77.

Budha, N.R., Lee, R., Hurdle, J.G., Lee, R.E. and Meibohm, B. (2009) Simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacterium tuberculosis. Tuberculosis (Edinb); 89:378-85.

Hurdle, J.G., Yendapally, R., Sun D and Lee, R.E. (2009) Evaluation of analogs of reutericyclin as prospective candidates for staphylococcal skin infections. Antimicrob. Agents Chemother. 53:4028-31.