Deqiang Sun, PhD
Center for Epigenetics & Disease Prevention
2121 W Holcombe Blvd.
Houston, TX 77030
Education and Training
Texas A&M University, College Station, Texas
Nanjing University, China
Dr. Sun specializes in the development of statistical methods and bioinformatics software, and the computational analysis on high-throughput sequencing data, such as Bisulfite-Seq, ChIP-Seq, and RNA-Seq, to extract biological insights especially in transcriptional and epigenetic regulation in development and diseases.
Dr. Sun’s primary research generally lies in bioinformatics, a growing research area where computational, mathematical, and statistical methods are applied to solve biological problems. Biology is digital by nature, demonstrated by the fact that all living organisms store their genetic information in DNA using 4 nucleotides. The detection of 5th and 6th nucleotides, 5-methylcytosine and 5-hydroxymethycytosine as epigenetic modification to nucleotide C, also becomes digital through popular bisulfite sequencing and promising single molecule direct sequencing. In addition to DNA methylation, the other two major epigenetic factors are histone modification and nucleosome positioning. Long Noncoding RNA has also gained attention in the past several years. With the fast growing technology, the question of how Epigenome interacts with Genome and Transcriptome is gradually approached with systematic computation using big data on genome scale.
Other Lab Members:
Assistant Research Scientist