Yun (Nancy) Huang
Yun Nancy Huang
, PhD
Assistant Professor

Office: Room 404 / Lab: Room 429
Center for Epigenetics and Disease Prevention 
Institute of Biosciences & Technology
Texas A&M University Health Science Center
2121 W. Holcombe Blvd, Houston, TX 77030
Phone: 713-677-7484 (office) 713-677-7485 (lab)
Faculty Bio

Education and Training

2003    Bachelor of Medicine (M.D. Equivalent),
              Zhejiang University, School of Medicine

2008    Ph.D. & M.S., Biochemistry, Georgia State University,
              Atlanta, GA

2009    Research Fellow, Immune Disease Institute,
              Harvard Medical School, Boston, MA
              Program in Cellular and Molecular Medicine at
              Children’s Hospital Boston

2010    Research Fellow, La Jolla Institute for Allergy and
              Immunology, La Jolla, CA

Research Interests

Imbalanced DNA methylation/demethylation results in abnormal gene expression and increased genome instability, which is frequently observed in human cancers. Dr. Huang ’s research interests are directed towards understanding how DNA methylation/demethylation balance is maintained in mammals and how aberrant DNA methylation and its oxidation products contribute to human cancer. Dr. Huang’s ongoing research includes using high-throughput sequencing to study the DNA modifications in human cancer, elucidating the role of DNA modification enzymes in mouse models, and exploring novel anti-cancer or preventive strategies by targeting key epigenetic pathways.

Dr. Huang has significantly contributed to the functional characterization of the ten eleven translocation (TET) enzymes in hematological malignancies. Dr. Huang also pioneered the use of innovative tools to probe the “sixth DNA base”, 5-hydroxymethylcytosine (5hmC), in the human genome and was among the first to profile the hydroxylmethylome in mouse embryonic stem cells. Her recent studies related to TET enzyme and 5hmC resulted in more than 15 peer-reviewed publications in top scientific journals and over 1,700 citations. She was recruited to the Texas A&M Health Science Center Institute of Biosciences & Technology as a CPRIT scholar in 2014.