Yubin Zhou

Yubin Zhou

Associate Professor

Center for Translational Cancer Research
2121 W. Holcombe Blvd.
Houston, TX   77030

Phone: 713-677-7483
Fax: 713-677-7779

Education and Training

Education

Bachelor of Medicine (M.D. Equivalent), Zhejiang University School of Medicine, 2003

M.S. Chemistry, Georgia State University, 2007

Ph.D. Biochemistry, Georgia State University, 2008

Postdoctoral Training

Research Fellow, Immune Disease Institute, Harvard Medical School 2008-2010

Instructor, La Jolla Institute for Allergy and Immunology, 2010-2012

Research Interests

The Zhou Lab is exploring the frontiers of calcium signaling, optogenetics, immunoengineering and molecular therapy research by combining biophysics, immunology, chemical biology, drug screening, computational biology and mouse genetics. We are focused on elucidating the role of calcium channels and DNA modifications in health and diseases and designing better treatment and prevention strategies for cardiovascular disorders, autoimmune diseases and cancer. Ongoing research activities include: i) discovering novel ion channels that govern intracellular calcium homeostasis and T cell activities; ii) devising innovative optical actuators for remote control of cell signaling, (epi)genome editing and immunomodulation; and iii) designing better treatment and prevention strategies for immunoinflammatory diseases and tumors. 

Recent Publications

Selected Publications (from a total of 60+ research papers)

Tan P, He L, Han G, and Zhou Y. Optogenetic immunomodulation: shedding light on the immune system. Trends in Biotechnology. 2017,35(3):215-26. (PMID: 27692897)  

Lee M, Li J, Liang Y, Ma G, Zhang J, He L, Liu Y, Li M, Sun D, Zhou Y# and Huang Y#. Engineered split-TET2 enzyme for inducible epigenetic remodeling. Journal of the American Chemical Society. 2017,139(13):4659-62. (PMID: 28294608; # lead contact) *Highlighted in ACS Editor’s Choice; Featured in JACS Spotlights and Vital Records.

Ma G, Wen S, Huang Y, Wang Y and Zhou Y. Optogenetic toolkit for precise control of calcium signaling. Cell Calcium. 2017 (PMID: 28104276).

He L, Jing J, Zhu L, Tan P, Ma G, Nhung NT, Wang J, Zhou Y#. and Huang Y#. Optogenetic control of membrane tethering and interorganellar communication at nanoscales. Chemical Science. 2017 (DOI: 10.1039/c7sc01115f; # lead contact).

Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Yao J, Ke L, Wang S, Park P, Marks J, Zhou Y, Zhou J, Heung MC, Liang H, Hu Z, Shen H, Hawke DH, Han L, Zhou Y, Lin C, and Yang L. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Nature Cell Biology. 2017, 19(3):238-51. (PMID: 28218907) *Highlighted in Nat Rev Mol Cel Bio.

Lei Y, Zhang X, Su J, Jeong M, Gundry MC, Huang YH, Zhou Y, Li W and Goodell MA. Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nature Communications. 2017 (accepted).

Zang S, Li J, Yang H, Zeng H, Han W, Zhang J, Lee M, Moczygemba M, Isgandarova S, Zhou Y, Rao A, Sun D, You J, and Huang Y. Mutational cooperativity of TET2 and RHOA disrupts peripheral T-cell homeostasis. Journal of Clinical Investigation. 2017 (accepted).

Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J Wang RF and Cui J. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune response. Molecular Cell. 2016,64:1-15. (PMID: 27666593)

Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Par PK, Zhou J, Zhou Y, Hu Z, Zhou Y, Mark JR, Liang H, Hung MC, Lin C, Yang L. The LINK-A lncRNA activates normoixc HIF1α signaling in triple-negative breast cancer. Nature Cell Biology. 2016,18(2):213-24. (PMID: 26751287).

Zhang Y, Huang L, Li Z, Ma G, Zhou Y# and Han G#. Illuminating cell signaling with near-infrared light-responsive nanomaterials. ACS Nano. 2016,10(4):3881-5 (PMID: 27077481; #corresponding authors) 

Jing J, He L, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Zhang SL, Shi X, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, and Zhou Y. Proteomic mapping of ER-PM junctions identifies STIMATE as a novel regulator of Ca2+ influx. Nature Cell Biology. 2015,17(10):1339-47. (PMID: 26322679). *Featured in NCB “News and Views”.

Ma G, Wei M, He L, Liu C, Wu B, Zhang SL, Jing J, Liang X, Senes A, Tan P, Li S, Sun A, Bi Y, Zhong L, Si H, Shen Y, Lee MS, Zhou W, Wang J, Wang Y, and Zhou Y. Inside-out Ca2+ signaling prompted by STIM1 conformational switch. Nature Communications. 2015,6:7826. (PMID: 26184105) *Featured in eBioTrade as Highlighted News.

He L, Zhang Y, Ma G, Tan P, Li Z, Zang S, Wu X, Jing J, Fang S, Zhou L, Wang Y, Huang Y, Han G, and Zhou Y. Near Infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. eLife. 2015,pii:e10024. (PMID: 26646180). *Highlighted in Biophotonics Magazine; Optics & Photonics News; ALN Magazine; The Battalion; Vital Records and Immuno-Oncology News.

Quintana A, Rajanikanth V, Farber-Katz S, Gudlur A, Zhang C, Jing J, Zhou Y, Rao A & Hogan PG. TMEM110 regulates the maintenance and remodeling of mammalian ER-Plasma membrane junctions competent for STIM-ORAI signaling. PNAS. 2015, 112(51):E7083-92. (PMID: 26644574).

Gudlur A*, Quintana A*, Zhou Y, Hirve N, Mahapatra S, Hogan PG. STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel. Nature Communications. 2014,5:5164 (PMID: 25296861).

Zhou Y, Srinivasan P, Razavi S, Seymour S, Meraner P, Stathopulos PB, Ikura M, Rao A, Hogan PG. Initial activation of STIM1, the regulator of store-operated calcium entry.  Nature Structural & Molecular Biology. 2013,20(8):973-81. (PMID: 23851458). *Featured in NSMB “News and Views.

Zhou Y, Ramachandran S, Oh-hora M, Rao A and Hogan PG. Pore architecture of the ORAI1 store-operated calcium channel. PNAS. 2010,107(11):4896-901. (PMID: 20194792)

Zhou Y, Meraner P, Kwon, HT, Machnes D, Oh-hora Masatsugu, Zimmer Jochen, Huang Y, Stura A, Rao A and Hogan PG. STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nature Structural & Molecular Biology. 2010,17(1):112-116. (PMID: 20037597). *Highlighted on the cover of NSMB; “Featured Article” on Nature Signaling Gateway; Rated as “Must Read [F1000 article factor: 8]”.

Full list available here.

Citations available here.