Fen Wang

Fen Wang

Professor

Center for Translational Cancer Research
2121 W. Holcombe Blvd
Houston, TX   77030

Phone: 713-677-7520
fwang@ibt.tamhsc.edu

Education and Training

Fen Wang earned his B.S. degree in microbiology and M.S. degree in cell biology at Xiamen University in Fujian, China.  He received a Ph.D. degree in biochemistry in 1994 in a joint program between Clarkson University, Postdam, New York, and the W. Alton Jones Cell Science Center, Lake Placid, New York. He was a postdoctoral fellow (1994 to 1996) and Assistant Research Scientist from 1997-1999 and promoted to Assistant Professor in 2000 in the Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, in the Texas Medical Center, Houston, Texas. He was promoted to tenured Associate Professor in 2006 and full professor in 2010.  He holds a joint appointment in the Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M Health Science Center.  In 2012 he assumed the directorship of the Center for Cancer and Stem Cell Biology.

Research Interests

The laboratory focuses on understanding the molecular basis of cell signaling, and how aberrant cell signaling leads to birth defects and causes cancers. Using in vitro cell culture systems and in vivo mouse models, we study how the fibroblast growth factor (FGF) activates its receptor (FF) tyrosine kinase, and how the activated FF transmits the signals to downstream targets and regulates proliferation, differentiation, homeostasis, and function of the cells, as well as in organogenesis and development, including prostate and cardiovascular system development. The laboratory also employs molecular biology, cell biology, and mouse genetic technologies to study how aberrant FGF signals promote tumor initiation, progression, and metastasis. In addition, how environmental factors contribute to tumorigenesis and congenital birth defects by modulating FGF signal intensity and specificity is also under the scope of our research interests.

Five Most Significant Publications prior to 2013 

Jin, C., K. McKeehan, W. Guo, S. Jauma, M. l. Ittmann, B. Foster, N. Greenberg, W. L. McKeehan, and F. Wang (2003) Cooperation between ectopic FGFR1 and depression of FGFR2 signaling in induction of high-grade prostatic intraepithelial neoplasia in mouse prostate. Cancer Res. 63: 8784-8790.

Lin Y, G. Liu, Y. Zhang, Y-P. Hu, K. Yu, C. Lin, K. McKeehan, J. W. Xuan, D. Ornitz, M. M. Shen, N. Greenberg, W. L. McKeehan, and F. Wang. (2007). Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and acquisition of strict androgen dependency for adult tissue homeostasis. Development 134: 723-734. (Feature of the Issue).

Zhang, Y., J. Zhang, Y. Lin, Y. Lan, C. Lin, J.W. Xuan, M.M. Shen, W.L. McKeehan, N.M. Greenberg, and F. Wang (2008).  Epithelial resident Fibroblast growth factor receptor substrate 2a-mediated signals in the prostate development, regeneration, and tumorigenesis. Development 135: 775-784 [Epub 2008 Jan 9].

Zhang J., Y. Lin, Y. Zhang, Y. Lan, C. Lin, A.M. Moon, R.J. Schwartz, J.F. Martin, F. Wang.  (2008) Frs2{alpha}-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.  Development. 135:3611-3622 [EPub 2008 Oct 2].

Zhang J., J. Liu, Y. Huang, J.Y.F. Chang, L. Liu, W.L. McKeehan, J.F. Martin, and F. Wang (2012) FRS2a-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. Circulation Research 110(4):e29-39 [Epub 2011 Dec 29]

Publications 2013

Wang, J.J., Z.X. Fang, H.M. Ye, P. You, M.J. Cai, H.B. Duan, F. Wang, and Z.Y. Zhang (2013) Clinical significance of overexpressed cyclin-dependent kinase subunits 1 and 2 in esophageal carcinoma.  Dis Esophagus. [Epub 2013 Jan 10] PMID: 23301842

Zhang, T., J. Liu, J. Zhang, E. B. Thekkethottiyil, T. L. Macatee, F.A. Ismat, F. Wang, J. Z. Stoller (2013) Jun is Required in Isl1-expressing Progenitor 1 Cells for Cardiovascular Development. PloS ONE. 8(2): e57032. doi:10.1371/journal.pone.0057032 [Epub 2013 Feb 21]

Yang, F., Y. Zhang., S.J Ressler., M.M. Ittmann, G.E. Ayala, T.D. Dang, F. Wang, D.R. Rowley (2013) FGFR1 is essential for prostate cancer progression and metastasis. Can Res. [Epub 2013 Apr 10] PMID: 23576558

Yang C., W. Lu, T. Lin, P. You, M. Ye, Y. Huang, X. Jiang, C. Wang, F. Wang, M.H. Lee, S.C. Yeung, R.L. Johnson, C. Wei, R.Y. Tsai, M.L. Frazier, W.L. McKeehan, Y. Luo (2013) Activation of liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol. 2013 Apr 17;13:67. doi: 10.1186/1471-230X-13-67. PMID:23590285

Cai Z., C. Tao, R. Ladher, N. Gotoh, G.S. Feng, F. Wang, X. Zhang (2013) Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development 140(13):2711-23. doi: 10.1242/dev.089987. Epub 2013 May 29. PMID:23720040

Gay D., O. Kwon, Z. Zhang, M. Spata, M.V. Plikus, P.D. Holler, M. Ito, Z. Yang, E. Treffeisen, C.D. Kim, A. Nace, X. Zhang, S. Baratono, F. Wang, D.M. Ornitz, S.E. Millar, G. Cotsarelis  (2013) Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nat Med. 2013 Jun 2. doi: 10.1038/nm.3181. [Epub ahead of print]

Wang C., J.Y.F. Chang, C. Yang, Y. Huang, J. Liu, P. You, W.L. McKeehan, F. Wang, X. Li (2013) Type 1 fibroblast growth factor receptor in cranial neural crest cells-derived mesenchyme is required for palatogenesis. J Biol Chem. 2013 Jul 26;288(30):22174-83. doi: 10.1074/jbc.M113.463620 [Epub 2013 Jun 10]  PMID: 23754280

Chang J.Y.F., C. Wang, C. Jin, C. Yang, Y. Huang, J. Liu, W.L. McKeehan, R.N. D’Souza, F. Wang (2013) Self-renewal and multilineage differentiation of mouse dental epithelial stem cells. Stem Cell Res. 2013 Jul 1;11(3):990-1002. doi: 10.1016/j.scr.2013.06.008. [Epub ahead of print] PMID: 23906788

Tien, J.C.Y., Z. Liu, L. Liao, F. Wang, Y. Xu, Y.L. Wu, N. Zhou, M. Ittmann, J. Xu (2013) The steroid receptor coactivator-3 is required for the development of castration resistant prostate cancer.  Can. Res 73:3997-4008 [Epub 2013 May 6] PMID: 23650284

Chang, J.Y.F., C. Wang, C. Jin, C. Yang, Y. Huang, J. Liu, R.N. D’Souza, W.L. McKeehan, F. Wang (2013) Fibroblast growth factor signaling is essential for self-renewal of tooth epithelial stem cells. J Biol Chem. 4;288(40):28952-28961 [Epub 2013 Aug 26] PMID: 23979135 

Corn P., F. Wang, W.L. McKeehan, N. Navone (2013) Targeting fibroblast growth factor pathways in prostate cancer. Clin Cancer Res [Epub 2013 Sep 19] PMID: 24052019

Publications 2014

Wang F., Y. Luo and W.L. McKeehan  (2014) The FGF Signaling Axis in Prostate Tumorigenesis  In:  E. Gelmann, C. Sawyers and F. Rauscher, eds. Molecular Oncology: Causes of Cancer and Targets for Treatment, pp190-203, Cambridge University Press (Academic Press).

Li H., C. Tao, Z. Cai, K. Hertzler-Schaefer, T.N. Collins, Y. Shao, F. Wang, G.-S. Feng, N. Gotoh, and X. Zhang (2014). FRS2a and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J. Cell Sci127: 571-582. [Epub ahead of print] PMID: 24284065; PMCID: PMC4007765

Jiang, X., X. Li, H. Huang, F. Jiang, Z. Lin, H. He, Y. Chen, F. Yue, J. Zou, Y. He, P. You, W. Wang, W. Yang, H. Zhao, Y. Lai, F. Wang, W. Zhong, and L. Liu (2013) Elevated Levels of Mitochondrion-associated Autophagy Inhibitor LRPPRC Are Associated with Poor Prognosis of Human Patients with Prostate Cancer. Cancer.  120(8):1228-1236. PMID: 24390809. PMCID: PMC3981875

Lin,  Z.Y., Y. Huang, Y.Q. Zhang, Z. Han, H. He, X. Ling, X. Fu, Q. Dai, C. Cai, J. Chen, Y. Liang, F. Jiang, W. Zhong, F. Wang, and C. Wu (2014). MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1. Int. J. Cancer 135(3):541-50.  PMID: 24382668

Phillips, T.D., M. Richardson, L. Chen, L. He, T.J. McDonald, L.H. Cizmas, S.H. Safe,  K.C. Donnelly, F. Wang, B. Moorthy, and G.-D. Zhou (2014) Mechanistic Relationships between Hepatic Genotoxicity and Carcinogenicity in Male B6C3F1 Mice Treated with Polycyclic Aromatic Hydrocarbon Mixtures. Archives of Toxicology89(6):967-77 PMID: 24888377 

Wang C., C. Yang, J. YF Chang, Y. Li, C. Jin, Y. Luo, P. You, X. Li, W. L. McKeehan, and F. Wang (2014) Hepatocyte FRS2a is Essential for the Endocrine Fibroblast Growth Factor to Limit the Amplitude of Bile Acid Production Induced by Prandial Activity.  Current Molecular Medicine.  14(6):703-711. PMID: 25056539

Wan, X., P. G. Corn, J. Yang, N. Palanisamy, M. W. Starbuck, E. Efstathiou, E. M. L. Tapia, A. Zurita, A. Aparicio, M. K. Ravoori, E. S. Vazquez, D. Robinson, Y-M Wu, X. Cao, M. Lyer, W. McKeehan, V. Kundra, F. Wang, P. Troncoso, A. M. Chinnaiyan, C. J. Logothetis, N. M. Navone1 (2014) Prostate cancer cell–bone cell cross-talk via FGFR1 mediates dovitinib antitumor activity in men with bone metastases. Science Translational Medicine. 2014 Sep 3; 6(252):252ra122. doi: 10.1126/scitranslmed.3009332. PMID: 25186177.

Jiang, X., W. Zhong, H. Huang, H. He, F. Jiang, Y. Chen, F. Yue, J. Zou, X. Li, Y. He, P. You, F. Wang, and L. Liu (2014) MAP1S-mediated Autophagy Is Activated during the Development of Prostate Adenocarcinomas Mol. Can. Res, (in press). PMID: 25043940

Lee, D-K, Y. Liu, L. Liao, F. Wang, and J. Xu (2014) The Prostate Basal Cell (BC) Heterogeneity and the p63-Positive BC Differentiation Spectrum in Mice International J. of Biological Science. 10(9):1007-17. PMID: 25210499.

Tien, J. C, L. Liao, Y. Liu, Z. Liu, D.-K. Lee, F. Wang and J. Xu (2014) The Steroid Receptor Coactivator-3 Is Required for Developing Neuroendocrine Tumor in the Mouse Prostate.  International J. of Biological Science.  10(10):1116-1127. PMID: 25332686 PMCID: PMC4202028

Publications 2015

Xu, C., W. Li, P. Qiu, Y. Xia, X. Du, F. Wang, L. Shen, Q. Chen, Y. Zhao, J. Rong, J. Wu, G. Liang, X. Li (2015) The therapeutic potential of a novel non-ATP-competitive fibroblast growth factor receptor 1 inhibitor on gastric cancer. Anticancer Drugs  26(4):379-387 PMID: 25521558

Lin, H., W. Liu, Z. Fang, X. Liang, J. Li, Y. Bai, L. Lin, H. You, Y. Pei, F. Wang, and Z-Y Zhang (2015). Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer. Science Reports.  5:9247.  PMID: 25782664; PMCID: PMC4363870

Ho, T.H., X.D. Liu, Y. Huang, C. Warneke, M. M Johnson, A. Hoang, P. Tamboli, F. Wang, and E. Jonasch (2015): The impact of FGFR1 and FRS2α expression on sorafenib treatment in metastatic renal cell carcinoma. BMC Cancer.15(1):304. PMID: 25900027; PMCID: PMC4406182

Huang, Y., C. Jin, T. Hamana, J. Liu, C. Wang, L. An, W. McKeehan, and F. Wang (2015) Overexpressed FGF9 in Prostate Cancer Cells Augments Reactive Stroma Formation and Promotes Prostate Cancer Progression. International J. of Biological Science (in press)

Liu, J., P. You, G. Chen, X. Fu, X. Zeng, C. Wang, Y. Huang,  L. An, X. Wan, N. Navone, C-L Wu, W. McKeehan, Z. Zhang, W. Zhong, and F. Wang (2015) Hyperactivated FRS2a-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients. Oncogene (in press) 

Huang, Y., T. Hamana, J. Liu, C. Wang, P. You, J. Y.F. Chang, Y. Luo, J. Xu, C. Jin, Z. Zhang, W. McKeehan, and F. Wang (2015) Prostate sphere-forming stem cells are derived from the P63-expressing basal compartment. J. Biol. Chem. PMID: 26032419.

Huang, Y., T. Hamana, J. Liu, C. Wang, P. You, J. Y.F. Chang, Y. Luo, J. Xu, C. Jin, Z. Zhang, W. McKeehan, and F. Wang (2015) Type 2 fibroblast growth factor receptor signaling preserves stemness and prevents differentiation of prostate stem cells from the basal compartment. J. Biol. Chem. PMID: 26032417.

Ye, W., J. Wang, Y. Song, D. Yu, C. Sun, C. Liu, F. Chen, Y. Zhang, F. Wang, R. P Harvey, L. Schrader, J. Martin, and Y. Chen (2015) A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaking cell fate in the pulmonary vein myocardium and sinoatrial node Development (in press)

For a complete list of publications, please visit: http://www.ncbi.nlm.nih.gov/sites/myncbi/fen.wang.1/bibliography/40852241/public/?sort=date&direction=ascending