Clifford Stephan

Clifford Stephan

Assistant Professor and Director

Center for Translational Cancer Research
2121 W. Holcombe Blvd
Houston, TX   77030

Phone: 713-677-7456
Fax: 713-677-7779
cstephan@ibt.tamhsc.edu

Education and Training

Vanderbilt University
Ph.D., Pharmacology
B.A., Chemistry & Molecular Biology

Postdoctoral Training
Brigham and Women’s Hospital, Harvard Medical School

Research Interests

  • Drug Discovery
  • High Throughput Drug Screening
  • Combinatorial Drug Screening

Peer Reviewed Publications

Elton TS, Stephan CC, Taylor GR, Kimball MG, Martin MM, Durand JN, et al. Isolation of two distinct type I angiotensin II receptor genes. Biochemical and biophysical research communications. 1992;184(2):1067-73. Epub 1992/04/30. PubMed PMID: 1575725.

Stephan CC, Sastry BV. Characterization of the subtype of muscarinic receptor coupled to the stimulation of phosphoinositide hydrolysis in 132-1N1 human astrocytoma cells. Cellular and molecular biology (Noisy-le-Grand, France). 1992;38(7):701-12. Epub 1992/11/01. PubMed PMID: 1282058.

Stephan CC, Sastry BV. Subtype of muscarinic receptor coupled to the attenuation of hormone-stimulated cAMP accumulation in NG108-15 neuroblastoma x glioma hybrid cells. Cellular and molecular biology (Noisy-le-Grand, France). 1992;38(5-6):601-12. Epub 1992/08/01. PubMed PMID: 1282846.

Stephan CC, Brock TA. Vascular endothelial growth factor, a multifunctional polypeptide. Puerto Rico health sciences journal. 1996;15(3):169-78. Epub 1996/09/01. PubMed PMID: 8994281.

Cunningham SA, Stephan CC, Arrate MP, Ayer KG, Brock TA. Identification of the extracellular domains of Flt-1 that mediate ligand interactions. Biochemical and biophysical research communications. 1997;231(3):596-9. Epub 1997/02/24. doi: 10.1006/bbrc.1997.6156. PubMed PMID: 9070853.

Tilton RG, Kawamura T, Chang KC, Ido Y, Bjercke RJ, Stephan CC, et al. Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. The Journal of clinical investigation. 1997;99(9):2192-202. Epub 1997/05/01. doi: 10.1172/jci119392. PubMed PMID: 9151791; PubMed Central PMCID: PMC508049.

Stephan CC, Chang KC, LeJeune W, Erichsen D, Bjercke RJ, Rege A, et al. Role for heparin-binding growth factors in glucose-induced vascular dysfunction. Diabetes. 1998;47(11):1771-8. Epub 1998/10/29. PubMed PMID: 9792547.

Rege AA, Bjercke RJ, Erichsen D, Owens R, Stephan CC, Brock TA. Development of novel monoclonal antibodies for the analysis of functional sites in FGF-2. Growth factors (Chur, Switzerland). 1999;16(3):161-9. Epub 1999/06/18. PubMed PMID: 10372957.

Tilton RG, Chang KC, LeJeune WS, Stephan CC, Brock TA, Williamson JR. Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF. Investigative ophthalmology & visual science. 1999;40(3):689-96. Epub 1999/03/06. PubMed PMID: 10067972.

De Vriese AS, Tilton RG, Elger M, Stephan CC, Kriz W, Lameire NH. Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes. Journal of the American Society of Nephrology : JASN. 2001;12(5):993-1000. Epub 2001/04/24. PubMed PMID: 11316858.

De Vriese AS, Tilton RG, Stephan CC, Lameire NH. Vascular endothelial growth factor is essential for hyperglycemia-induced structural and functional alterations of the peritoneal membrane. Journal of the American Society of Nephrology : JASN. 2001;12(8):1734-41. Epub 2001/07/20. PubMed PMID: 11461947.

Phatak SS, Stephan CC, Cavasotto CN. High-throughput and in silico screenings in drug discovery.  Expert Opin. Drug Discov., 2009;4:947-959.

Ding Z, German P, Bai S, Feng Z, Gao M, Si W, et al. Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis. Journal of biomolecular screening. 2012;17(5):572-80. Epub 2012/02/24. doi: 10.1177/1087057112436557. PubMed PMID: 22357874.