Praveen Rajendran

Praveen Rajendran

Assistant Professor

Center for Epigenetics & Disease Prevention
2121 W. Holcombe Blvd.
Houston, TX   77030-3303

Phone: 713-677-7803
Fax: 713-677-7784
prajendran@ibt.tamhsc.edu

Education and Training

Praveen Rajendran received his Bachelor of Pharmacy (B. Pharm) degree with Honors in 1994 and his Ph.D. degree in Pharmacology in 2006 from Birla Institute of Technology & Science (BITS), Pilani, India. He earned a Post Graduate Diploma in Business Management (MBA equivalent) in 1998 from IMT-G, India. After completing doctoral studies Dr. Rajendran spent three years in Pharma R&D from 2006-09, where he was part of preclinical development teams in Cancer biology. He carried out his post-doctoral work at the Linus Pauling Institute, Oregon State University from 2009-13. Dr. Rajendran joined the faculty as an Assistant Professor in 2014 in the Center for Epigenetics and Disease Prevention (CEDP), Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas.

Research Interests

Dr. Rajendran has a broad background in pharmacology with over 20 years of experience and a proven record of accomplishment in cancer chemoprevention, preclinical research, drug discovery & development.  His research relates to identifying novel epigenetic approaches to the treatment and prevention of colorectal cancer, where most therapeutic options are woefully ineffective. He identified turnover of histone deacetylases (HDACs) triggering protein acetylation as a novel mechanism for cancer chemoprevention by dietary isothiocyanates.  His lab routinely employs both cell-based and rodent animal models that made it possible to conduct clinical trials with dietary isothiocyanates, such as sulforaphane. 

In addition, he serves as the primary investigator in studies that test the hypothesis that isothiocyanates exploit HDAC turnover pathways, faulty DNA repair mechanisms, and genomic instability in cancer cells, leading to chemo-sensitization and the potential for enhanced cancer therapy.

His expertise in working with NSAID-like drugs and dietary compounds combined with knowledge of histone and non-histone protein acetylation has resulted in collaborative efforts with GI clinicians at MD Anderson Cancer Center, DNA repair scientists at Methodist, proteomics experts at Baylor College of Medicine, plant circadian specialists at Rice University, and pharmacokinetic experts at the University of Houston.

Praveen recently assumed leadership of the Antibody & Biopharmaceutics Core (ABC), a brand new service center focused on antibody engineering.  As ABC Director, Praveen supports and advances the research mission of the IBT, maximize return on investment, and promote ‘Team Science’ at all levels. For more details, see https://ibt.tamhsc.edu/cores/abcore/index.html

Selected Publications

 

Rajendran P, Johnson GS, Li L , Chen YS, Dashwood WM, Nguyen N, Ulusan A, Ertem FU, Zhang M, Li J, Sun D, Huang Y, Wang S, Leung HCE, Lieberman D, Beaver LM, Ho E, Bedford MT, Chang KS, Vilar E, Dashwood RH. CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition. Cancer Res 2019 Jan 14 (Epub ahead of print).

Okonkwo A, Mitra J, Johnson GS, Li L, Dashwood WM, Hegde ML, Yue C, Dashwood RH, Rajendran P. Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs. Mol Nutr Food Res. 2018 Jun 20:e1800228.

Johnson GS, Li J, Beaver LM, Dashwood WM, Sun D, Rajendran P, Williams DE, Ho E, Dashwood RH.  A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.  Mol Nutr Food Res. 2017 Apr;61(4).

Ertem FU, Zhang W, Chang K, Dashwood WM, Rajendran P, Sun D, Abudayyeh A, Vilar E, Abdelrahim M, Dashwood RH.  Oncogenic targets Mmp7, S100a9, Nppb and Aldh1a3 from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam.  Int J Cancer. 2017 Jan 15;140(2):460-468.

Ertem F, Dashwood WM, Rajendran P, Raju G, Rashid A, Dashwood R.  Development of a murine colonoscopic polypectomy model (with videos).  Gastrointest Endosc. 2016 Jun;83(6):1272-6.

Rajendran P, Dashwood WM, Li L, Kang Y, Kim E, Johnson G, Fischer KA, Löhr CV, Williams DE, Ho E, Yamamoto M, Lieberman DA, Dashwood RH. Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. Clin Epigenetics. 2015 Sep 18;7(1):102.

Kim E, Bisson WH, Löhr CV, Williams DE, Ho E, Dashwood RH, Rajendran P. Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors. Curr Top Med Chem. 2016;16(7):714-31.

Rajendran P, Kidane A, Yu TW, Dashwood M, Williams DE, Ho E, Dashwood RH. HDAC turnover, CtIP acetylation, and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics. 2013 Jun;8(6):612-23.

Rajendran P and Dashwood RH. Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clinical Epigenetics. 2011;3:4.

Rajendran P, Delage B, Dashwood WM, Yu TW, Wuth B, Williams DE, Ho E and Dashwood RH. Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol. Cancer. 2011 May 30;10(1):68.

Rajendran P, Williams DE, Ho E, Dashwood RH. Metabolism as a key to histone deacetylase inhibition. Crit. Rev. Biochem. Mol. Biol. 2011;46(3):181-99.

Rajendran P, Jaggi M, Singh MK, Mukherjee R, Burman AC. Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity. Invest New Drugs. 2008 Feb;26(1):25-34.

For a complete list of publications, please visit: http://www.ncbi.nlm.nih.gov/pubmed/?term=rajendran+praveen

US Patents

  1. Histone deacetylase inhibitors. 8,476,255. July 2, 2013.
  2. Histone deacetylase inhibitors. 8,450,525. May 28, 2013.
  3. Biocompatible, non-biodegradable, non-toxic polymer useful for nanoparticle pharmaceutical compositions. 8,338,562. December 25, 2012.
  4. Betulinic acid derivatives. 8,022,055. September 20, 2011.
  5. Antiangiogenic drugs. 6,492,330. December 10, 2002.
  6. Betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis 6,403,816. June 11, 2002.
  7. Antiangiogenic activity of betulinic acid and its derivatives. 6,228,850. May 8, 2001.