Education and Training
2011~2013 Assistant Research Scientist
CTCR, IBT, Texas A&M Health Science Center
2010~2011 Research Investigator
University of Texas, M. D. Anderson Cancer Center
2007~2010 Invited Senior Researcher, Korea Research Institute
of Bioscience and Biotechnology (KRIBB), South Korea
2004~2007 Postdoctoral Fellow, KRIBB, South Korea
2001~2002 Researcher, Hanwha Chemical R&D Center,
1996~2001 Researcher, KRIBB, South Korea
1996~2004 Ph.D., Department of Biological Sciences
Korea Advanced Institute of Science and Technology
(KAIST), South Korea
1994~1996 M.S., Department of Life Sciences, KAIST, South Korea
1986~1990 B.S., Department of Biology, KAIST, South Korea
Microtubules are involved in a number of cellular processes including cell shape, cell polarity, transport of organelles and vesicles, cell migration and invasion, mitotic spindle and midbody during mitosis and cytokinesis, centrosome, primary cilia and flagella, and projection of axon and dendrite in neuron cells. A number of posttranslational modifications (PTM) of tubulin proteins has been known to involve in specialized microtubule structures and functions. The PTMs of tubulins include detyrosination, Δ2-tubulin generation, polyglutamylation, polyglycylation and acetylation on K40 of α-tubulin. Abnormal regulation of the microtubule PTMs promotes neurodegeneration, ciliopathies and cancers. Microtubule targeting agents (MTAs) have been successfully used for cancer therapy by inhibiting microtubule functions. However, they currently have limitations for cancer therapeutics due to a highly incidence of neuropathic side effects, possible mutagenic properties leading to chromosome instability, and drug resistance by ectopic expressions of MTA-resistant isotypes of βIII-tubulin in cancers. Therefore, a new strategy to overcome the drug resistance to MTAs and their side effects should be developed for cancer therapeutics. Our laboratory is currently studying about a novel PTM of microtubules and its roles on microtubule functions in cells. We are investigating the responsible proteins involved in the modification (writer), recognition (reader), and demodification (eraser) of the novel PTM. Our study about the new PTM of microtubule will provide an alternative strategy of drug development for cancer therapeutics.
Sohn, B. H.*, Park, I. Y.*, Lee, J. J., Yang, S. -J., Jang, Y,. Park, K. C., Kim, D. J., Lee, D. C., Sohn, H. A., Kim, T. W., Yoo, H. -S., Choi, J. Y., Bae, Y. S. & Yeom, Y. I. (2010). Functional switching of TGFβ1 signaling in liver cancer by epigenetic modulation of a single CpG site in TTP promoter. Gastroenterology. 138(5),1898-1908. *Co-first author.
Min, S. -H., Kim, D. M., Kim, M. N., Ge, J., Lee, D. C., Park, I. Y., Park, K. C., Hwang, J. -S., Cho, C. -W., & Yeom, Y. I. (2010). Gene delivery using a derivative of the protein transduction domain peptide, K-Antp. Biomaterials, 31(7), 1858-64.
Sohn, J. K., Sohn, B. H., Park, I. Y., Lee, S. U., Fa, L., Chang, K. Y., Shin, J. H. & Lee, Y. I. (2009). Hepatitis B virus-X protein recruits histone deacetylase 1 to repress insulin-like growth factor binding protein 3 transcription. Virus Research, 139(1), 14-21.
Lee, D. C., Kang, Y. K., Kim, W. H., Jang, Y. J., Kim, D. J., Park, I. Y., Sohn, B. H., Sohn, H. A., Lee, H. G., Lim, J. S., Kim, J. W., Song, E. Y., Kim, D. M., Lee, M. -N., Oh, G. T., Kim, S. J., Park, K. C., Yoo, H. S., Choi, J. Y. & Yeom, Y. I. (2008). Functional and clinical evidence for NDRG2 as a candidate suppressor of liver cancer metastasis. Cancer Research, 68(11), 4210-20.
Park, I. Y.*, Sohn, B. H.*, Yu, E., Chung, Y. -H., Surzycki, S. J. & Lee. Y. I. (2007). Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology, 132(4), 1476-94. *Co-first author.
Yang, I., Park, I. Y., Jang, S. -M., Shi, L. H., Ku, H. -K., & Park, S. -R. (2006). Rapid quantification of DNA methylation through dNMP analysis following bisulfite-PCR. Nucleic Acids Research, 34(8), e61.
Park, I. Y., Sohn, B. H., Choo, J. H., Joe, C. O., Seong, J. K., Lee, Y. I. & Chung, J. H. (2005). Deregulation of DNA methyltransferases and loss of parental methylation at the Insulin-like growth factor II (Igf2)/H19 loci in p53 knockout mice prior to tumor development. Journal of Cellular Biochemistry, 94(3), 585-96.
Yoon, S. W., Park, I. Y., Sohn, B. H., Lee, J., Yeo, W. H. & Lee, Y. K. (2004). A new compound from Micromonospora sp. SA246, 9-hydroxycrisamicin-A, activates hepatitis B virus replication. Biochemical and Biophysical Research Communications, 319(3), 859-865.
Koo, D. K., Kang, Y. K., Choi, Y. H., Park, J. S., Han, S. K., Park, I. Y., Kim, S. U., Lee. K. K., Son, D. S., Chang, W. K. & Han, Y. M. (2000). In vitro development of reconstructed porcine oocytes after somatic cell nuclear transfer. Biology of Reproduction, 63(4), 986-92.
Han, Y. M., Kim, S. J., Park, J. S., Park, I. Y., Kang, Y. K., Lee, C. S., Koo, D. B., Lee, T. H., Yu, D. Y., Kim, H., Lee, K. J. & Lee, K. K. (2000). Blastocyst viability and generation of transgenic cattle following freezing of in vitro produced, DNA-injected embryos. Animal Reproduction Science, 63(1-2), 53-63.
Lee, S. W., Park I. Y., Hahn Y., Lee, J. E., Seong, C. S., Chung, J. H. & Park, Y. S. (1999). Cloning of mouse sepiapterin reductase gene and characterization of its promoter region. Biochimica Biophysica Acta, 1445(1), 165-71.
Kim, S. J., Sohn, B. H., Jeong, S. K., Park, K. W., Park, J. S., Park, I. Y., Lee, T. H., Choi, Y. H., Lee, C. S., Han, Y. M., Yu, D. Y. & Lee, K. K. (1999). High-level expression of human lactoferrin in milk of transgenic mice using genomic lactoferrin sequence. Journal of Biochemistry, 126(2), 320-5.
Han, Y. M., Kim, S. J., Yu, D. Y., Park, J. S., Lee, C. S., Jung, S. K., Park, I. Y., Sohn, B. H., Choi, Y. H., Nam, M. S., Lee, H. T., Chung, B. H., Chung, K. S., Ko, D. H., Kim, Y. H., Yang, C. S., Yoo, O. J. & Lee, K. K. (1997). Studies on the generation of transgenic cow producing human lactoferrin in the milk. Korean Journal of Animal Reproduction, 20(4), 371-378.