Jiang Chang

Jiang Chang

Associate Professor, Director Houston Graduate Program

Center for Translational Cancer Research
2121 W. Holcombe Blvd.
Houston, TX   77030

Education and Training

M.D. Wuhan University School of Medicine, Wuhan, China

Ph.D., Texas A&M University, College Station, Texas

Postdoc, Baylor College of Medicine, Houston, Texas

Research Interests

Heart failure (impaired ventricular pump function) is an eventual outcome for diverse cardiovascular disorders and the leading cause of combined morbidity and mortality in the United States and other developed industrial nations. The focus of my lab is to understand the molecular mechanisms that initiate and mediate the pathogenesis of maladaptive cardiac remodeling, such as cardiac hypertrophy and fibrosis. The overall approach consists of using molecular and genetic engineering mouse models by generating constitutive and inducible transgenic mice as well as straight and conditional knockout mice with different cardiomyopathy.

Recent Publications

2016

Baohui Liu, Huimin Dong, Xi Lin, Xiangsheng Yang, Xiaojing Yue, Jian Yang, Yuntao Li, Liquan Wu, Xiaonan Zhu, Shenqi Zhang, Daofeng Tian, Junmin Wang, Qiang Cai, Shanping Mao, Qianxue Chen, Jiang Chang.  RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion.  Impact Journals. October 1, 2016.

Yue X, Lin X, Yang T, Yang X, Yi X, Jiang X, Li X, Li T, Guo J, Dai Y, Shi J, Wei L, Youker KA, Torre-Amione G, Yu Y, Andrade KC, Chang J. Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis. Hypertension2016; 67(3):597-605. NIHMSID: NIHMS746184 PubMed [journal] PMID: 26781283 PMCID: PMC4752414 

2015

Jie W, Andrade KC, Lin X, Yang X, Yue X, Chang JPathophysiological Functions of Rnd3/RhoEComprehensive Physiology. 2015; 6(1):169-86. PubMed [journal]  PMID: 26756630

Liu B, Lin X, Yang X, Dong H, Yue X, Andrade KC, Guo Z, Yang J, Wu L, Zhu X, Zhang S, Tian D, Wang J, Cai Q, Chen Q, Mao S, Chen Q, Chang J.  Downregulation of RND3/RhoE in glioblastoma patients promotes tumorigenesis through augmentation of notch transcriptional complex activity. Cancer Medicine 2015 Jun 24. doi: 10.1002/cam4.484. [Epub ahead of print].  PMID: 26108681. PMCID: PMC4567025

Kim EY, Zhang Y, Ye B, Segura AM, Beketaev I, Xi Y, Yu W, Chang J, Li F, Wang J. Involvement of activated SUMO-2 conjugation in cardiomyopathy. Biochim Biophys Acta 2015; 1852(7):1388-99. PubMed [journal] PMID: 25857621

Yang X, Wang T, Lin X, Yue X, Wang Q, Wang G, Fu Q, Ai X, Chiang DY, Miyake CY, Wehrens XH, Chang JGenetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circulation Research 2015; 116(1):e1-e10. NIHMSID: NIHMS638385. PubMed [journal] PMID: 25348166 PMCID: PMC4282622

Kim EY, Zhang Y, Beketaev I, Segura AM, Yu W, Xi Y, Chang J, Wang J. SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy Journal of Molecular and Cellular Cardiology 2015; 78:154-64. PubMed [journal] PMID: 25128087

2014

Wang X, Huang W, Liu G, Cai W, Millard RW, Wang Y, Chang J, Peng T, Fan GC. Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. Journal of Molecular and Cellular Cardiology 2014; 74:139-50. NIHMSID: NIHMS595036 PubMed [journal] PMID: 24825548 PMCID: PMC4120246

Yue X, Yang X, Lin X, Yang T, Yi X, Dai Y, Guo J, Li T, Shi J, Wei L, Fan G, Chen C, Chang JRnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failureCell Death and Disease. 2014 Jun 5;5:e1284. doi: 10.1038/cddis.2014.235. PubMed PMID: 24901055 PMCID: PMC4611712

Wang X, Huang W, Yang Y, Wang Y, Peng T, Chang J, Caldwell CC, Zingarelli B, Fan GC.  Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis. Biochim Biophys Acta 2014; 1842(5):701-11. NIHMSID: NIHMS561798 PubMed [journal] PMID: 24486439 PMCID: PMC3959587

Surma M, Handy C, Chang J, Kapur R, Wei L, Shi J.  ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment. PloS ONE. 2014; 9(3):e90758. PubMed [journal] PMID: 2 4595357 PMCID: PMC3942480

2013

Lin X, Liu B, Yang X, Yue X, Diao L, Wang J, Chang J.  Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling.  Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(20):8236-41.  PubMed [journal] PMID: 23630292 PMCID: PMC3657816

Lin X, Liu B, Yang X, Yue X, Chang JRnd3 deficiency results in aqueductal stenosis contributing to hydrocephalus through upregulation of Notch signalingPro Nat Acad Sci USA, 2013 May 14;110 (20):8236-41. doi: 10.1073/pnas.1219995110. Epub 2013 Apr 29. PubMed PMID: 23630292 PubMed Central PMCID: PMC3657816.

Li Q, Guo J, Lin X, Yang X, Ma Y, Fan GC, Chang JAn intragenic SRF-dependent regulatory motif directs a cardiac-specific microRNA-1-1/133a-2 expressionPloS ONE, 8(9): e75470. doi:10.1371/journal.pone.0075470. Epub 2013 September 13. PubMed PMID: 24058688 PubMed Central PMCID: PMC3772891.

2012

Yang X, Li Q, Lin X, Ma Y, Yue X, Tao Z, Wang F, McKeehan W, Wei L, Schwartz R, Chang JMechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1FASEB Journal. Published online January 25 2012.  PubMed PMID: 22278938 PubMed Central PMCID: PMC3336781

Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J. Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. Journal of Molecular and Cellular Cardiology 2012; 52(3):638-49. NIHMSID: NIHMS342248 PubMed [journal] PMID: 22155005 PMCID: PMC3294171

Wong J, Zhang J, Yanagawa B, Luo Z, Yang X, Chang J, McManus B, Luo H. Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac gene expressionCell Research. Jul. 19.doi:10.1038/cr. 2011.114. [Epub ahead of print] PubMed PMID: 21769134 PubMed Central PMCID: PMC3271589.

Lin X, Yang X, Li Q, Ma Y, Cui S, He D, Lin X, Schwartz RJ, Chang J.  Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway. Molecular and Cellular Biology 2012; 32(2):297-308. PubMed [journal] PMID: 22106411 PMCID: PMC3255775

Zhou CC, Chang J, Mi T, Abbasi S, Gu D, Huang L, Zhang W, Kellems RE, Schwartz RJ, Xia Y.  Targeted expression of Cre recombinase provokes placental-specific DNA recombination in transgenic mice. PloS ONE. 2012; 7(2):e29236. PubMed [journal] PMID: 22363401 PMCID: PMC3281813

Zhang X, Wang X, Zhu H, Kranias EG, Tang Y, Peng T, Chang J, Fan GC.  Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2.  PloS ONE. 2012; 7(3):e32765.  PubMed [journal] PMID: 22427880 PMCID: PMC3299679

Lin X, Yang X, Li X, Ma Y, Cui S, He D, Lin X, Schwartz R, Chang JProtein tyrosine phosphatase‐like A regulates myoblast proliferation and differentiation through MyoG and cell cycling signaling pathwayMolecular and Cellular Biology. 32:297-308; 2012.  PubMed PMID: 22106411 PubMed Central PMCID: PMC3255775.

2011

Zhang L, Valdez JM, Zhang B, Wei L, Chang J, Xin L.  ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PloS one. 2011; 6(3):e18271. PubMed [journal] PMID: 21464902 PMCID: PMC3065488

Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J.  Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects. PloS ONE. 2011; 6(6):e20803. PubMed [journal] PMID: 21677783 PMCID: PMC3108998

2010

Li Q, Lin X, Yang X, Chang JNFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repressionAm J Physiol Heart Circ Physiol 298:H1340-H1347, 2010.  PubMed PMID: 20173049 PubMed Central PMCID: PMC3774484.

Older Publications

J. Chang, Z. Mao and C. Deng.  Application of mathematical method in early diagnosis of gastric carcinoma. Appl Stat Manag 50(6):4-7; 1990.
 
W. Xie and J. Chang.  An electrocardiogram analysis of arrhythmia in 109 cases with acute cerebrovascular disease.  Wuhan Univ J Med 12(2): 182-183; 1991.
 
J. Chang and C. Deng.  Prostaglandin and the gastric mucosal protection. Foreign Med (Internal Med) 19(4):169-172; 1992.
 
J. Chang, C. Deng, P. Shen and Y. Xie.  Protective effect of radix salviae miltiorrhize on ethanol-induced gastric mucosal damage in rats and mechanism. J Pathophysiol 10(1):27-30; 1994.

L. Sun, J. Chang, S.R. Kirchhoff, A.A. Knowlton.  Activation of HSF and selective increase in heat shock proteins by acute dexamethasone treatment. American Journal of Heart and Circulatory Physiology 278:H1091-H1097; 2000.

J. Chang, A.A. Knowlton and J.S. Wasser. Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance. American Journal of Physiology 278:R209-R214; 2000.

J. Chang, A.A. Knowlton, F. Xu and J.S. Wasser. Activation of the heat shock response: relationship to energy metabolites A 31P NMR study in rat heartsAmerican Journal of Heart and Circulatory Physiology 280:H426-H433; 2001.

J. Chang, J.S. Wasser, R.N. Cornelussen and A.A. Knowlton. Activation of heat-shock factor by stretch-activated channels in rat hearts. Circulation 104:209-14; 2001.

J. Chang, L. Wei, T. Otani, K.A. Youker, M.L. Entman and R.J. Schwartz. Inhibitory cardiac transcription factor, SRF-N, is generated by caspase3 cleavage in human heart failure and attenuated by ventricular unloading. Circulation 108:407-413; 2003.

Y. Zhang, J. Bo, G.E. Taffet, J. Chang, A. Reddy, L.H. Michael, M.D. Schneider, M.L. Entman, R.J. Schwartz and L. Wei. Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis. FASEB J 20:916-925, 2006

J. Chang, M. Xie, V. Shah, M.D. Schneider, M.L. Entman, L. Wei and R.J. Schwartz. Activation of ROCK-1 by Caspase-3 Cleavage Plays an Essential Role in Cardiac Myocyte Apoptosis. Proc Natl Acad Sci USA 103:14495-500; 2006

V. R. Shah, M. I. Koster, D. R. Roop, D. M. Spencer, L. Wei, Q. Li, R. J. Schwartz and J Chang. Double-inducible gene activation system for caspase 3 and 9 in epidermis. Genesis 45:194-199, 2007.

D.F. Chang, N.S.Belaguli, Jiang Chang and R.J. Schwartz. LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes. Pro Nat Acad Sci USA 104:157-162, 2007.  PubMed PMID: 17185421 PubMed Central PMCID: PMC1765427.
 
Q. Li, X. Lin, X. Yang and J. Chang. NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repressionAmerican Journal of Heart and Circulatory Physiology 298:H1340-H1347, 2010.  PubMed PMID: 20173049 PubMed Central PMCID: PMC3774484.