Jiang Chang

Jiang Chang


Center for Translational Cancer Research
2121 W. Holcombe Blvd.
Houston, TX   77030

Education and Training

M.D. Wuhan University School of Medicine, Wuhan, China

Ph.D., Texas A&M University, College Station, Texas

Postdoc, Baylor College of Medicine, Houston, Texas

Research Interests

Heart failure (impaired ventricular pump function) is an eventual outcome for diverse cardiovascular disorders and the leading cause of combined morbidity and mortality in the United States and other developed industrial nations. The focus of my lab is to understand the molecular mechanisms that initiate and mediate the pathogenesis of maladaptive cardiac remodeling, such as cardiac hypertrophy and fibrosis. The overall approach consists of using molecular and genetic engineering mouse models by generating constitutive and inducible transgenic mice as well as straight and conditional knockout mice with different cardiomyopathy. The ultimate goal of our efforts is to provide clinical translation for the prevention and treatment of pathological cardiac remodeling from our mechanistic studies.

Selected Publications

  1. Yuan Dai, Jiangping Song, Wenjiao Li, Tingli Yang, Xiaojing Yue, Xi Lin, Xiangsheng Yang, Weijia Luo, Junli Guo, Xin Wang, Songqing Lai, Kelsey C. Andrade, Jiang Chang. RhoE Fine-Tunes Inflammatory Response in Myocardial Infarction Circulation. In press. Oct. 2018.

  2. Yuan Dai, Weijia Luo, Jiang Chang. Rho kinase signaling and cardiac physiology. Cur Opin in Physiol. 2018; 1:14-20. NIHMSID: NIHMS922648. PMID:29527586 PMCID: PMC5842951. (Inaugural issue).

  3. Jin Cao, Yi Yu, Zhengmao Zhang, Xi Chen, Zhaoyong Hu, Qiang Tong, Jiang Chang, Xin-Hua Feng and Xia Lin. SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation. Diabetes. Aug. 2017; db170546. PMID: 28851713 PMCID: PMC5741142 (Co-corresponding author).

  4. Xin Yi, Ye Tao, Xi Lin, Yuan Dai, Tingli Yang, Xiaojing Yue, Xuejun Jiang, Yan Li, Ding-sheng Jiang, Kelsey C. Andrade, Jiang Chang. Histone methyltransferase Setd2 is critical for the proliferation and differentiation of myoblasts. BBA-Mol Cell Res. 2017 Jan 24. pii: S0167-4889(17)30020-4. doi: 10.1016/j.bbamcr.2017.01.012. PMID:28130125.

  5. Xiaojing Yue, Xi Lin, Tingli Yang, Xiangsheng Yang, Xin Yi, Xuejun Jiang, Xiaoyan Li, Junli Guo, Tianfa Li, Yuan Dai, Jianjian Shi, Lei Wei, Keith A. Youker, Guillermo Torre-Amione, Yanhong Yu, Kelsey C. Andrade, and Jiang Chang. Rnd3/RhoE Modulates HIF1α and regulates responsive cardiac angiogenesis. Hypertension. 2016 Jan 18. pii: HYPERTENSIONAHA.115.06412. [Epub ahead of print] PMID: 26781283 PMCID: PMC4752414

  6. Xiangsheng Yang, Tiannan Wang, Li, Xi Lin, Xiaojing Yue, Qiongling Wang, Guangliang Wang, Qin Fu, Xun Ai, David Y. Chiang, Christina Y. Miyake, Xander H.T. Wehrens and Jiang Chang. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Cir Res. 2015 Jan 2;116(1):e1-e10. doi: 10.1161/CIRCRESAHA.116.304940. Epub 2014 Oct 27. PubMed PMID: 25348166; PubMed Central PMCID: PMC4282622.

  7. Xiaojing Yue, Xiangsheng Yang, Xi Lin, Tingli Yang, Xin Yi, Yuan Dai, Junli Guo, Tianfa Li, Jianjian Shi, Lei Wei, Guo-Chang Fan, Conan Chen and Jiang Chang. Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell Death Dis. 2014 Jun 5;5:e1284. doi: 10.1038/cddis.2014.235. PubMed PMID: 24901055.

  8. Xi Lin, Baohui Liu, Xiangsheng Yang, Xiaojing Yue and Jiang Chang. Rnd3 deficiency results in aqueductal stenosis contributing to hydrocephalus through upregulation of Notch signaling. Pro Nat Acad Sci USA, 2013 May 14;110 (20):8236-41. doi: 10.1073/pnas.1219995110. Epub 2013 Apr 29. PubMed PMID: 23630292 PubMed Central PMCID: PMC3657816.

  9. Xiangsheng Yang, Qi Li, Xi Lin, Yanlin Ma, Xiaojing Yue, Zhenyin Tao, Fen Wang, Wallace L. Mckeehan, Lei Wei, Robert J. Schwartz and Jiang Chang. Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1. FASEB Journal. Published online January 25 2012.  PubMed PMID: 22278938 PubMed Central PMCID: PMC3336781

  10. Xi Lin, Xiangsheng Yang, Qi Li, Yanlin Ma, Shuang Cui, Dacheng He, Xia Lin, Robert J. Schwartz and Jiang Chang. Protein tyrosine phosphatase‐like A regulates myoblast proliferation and differentiation through MyoG and cell cycling signaling pathway. Mol and Cell Bio. 32:297-308; 2012. PubMed PMID: 22106411 PubMed Central PMCID: PMC3255775.

Complete List of Publications