Informatics Platform & Analysis

In addition to expertise, we have built significant computational infrastructure to handle the large volume of data produced in phenotypic screening. Key computations systems include: A dedicated image analysis server with 40 logical processors, 192 GB of RAM, GPU processor, and 20 Tb of local storage; 4 peripheral workstations each with at least 10 logical processors, 64 GB of RAM, and a GPU; A centralized data server with a storage capacity of 100Tb. All computational resources can be utilized as a single unit using server management and task automation tools in Pipeline Pilot.

  • Statistical services
    • Assay design optimization
    • Assay performance evaluation
    • Data normalization and integration
    • Exploratory analysis
    • Development of automated classifiers using state-of-art machine learning techniques
  • Image analysis services
    • Development of custom image analysis
    • Upscaling of established protocols
    • Experience with monolayers, organoids, spheroids, and time lapse data
  • Bio- and Chemi-informatics support
    • Chemical space profiling
    • Quantative structure activity relationship
    • Biomarker discovery
    • Knowledge base mining
    • High dimensional data embedding
  • Key software and programming languages
    • Pipeline Pilot from Biovia
    • Matlab from Mathworks
    • Prism from Graphpad
    • R programing language
    • Python programing language
    • IN Cell Developer from GE Life Sciences
    • MetaXpress from Molecular Devices
    • ImageJ from NIHs
    • CellProfiler from the Broad Institute
    • Ingenuity Pathway Analysis from Qiagen
    • Excel from Microsoft
    • Spotfire from TIBCO Software Inc.
  • Key Computational infrastructure
    • Dell T630 server with dual Xenon processors, 192 GB RAM
    • 4 peripheral workstations each with at least 10 core Xenon processor, 64 GB RAM
    • Centralized 100 Tb data storage server
    • Server integration software