Publications

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Recent Publications (Since 2000):

Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJ.

Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14495-500. Epub 2006 Sep 18.

Schwartz RJ, Schneider MD.

CAMTA in cardiac hypertrophy. Cell. 2006 May 5;125(3):427-9. Review.

Iyer D, Chang D, Marx J, Wei L, Olson EN, Parmacek MS, Balasubramanyam A, Schwartz RJ.

Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4516-21. Epub 2006 Mar 13.

Chi X, Chatterjee PK, Wilson W 3rd, Zhang SX, Demayo FJ, Schwartz RJ.

Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13490-5. Epub 2005 Sep 6.

Niu Z, Yu W, Zhang SX, Barron M, Belaguli NS, Schneider MD, Parmacek M, Nordheim A, Schwartz RJ.

Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem. 2005 Sep 16;280(37):32531-8. Epub 2005 May 31.

Zhang SX, Garcia-Gras E, Wycuff DR, Marriot SJ, Kadeer N, Yu W, Olson EN, Garry DJ, Parmacek MS, Schwartz RJ.

Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation. J Biol Chem. 2005 May 13;280(19):19115-26. Epub 2005 Jan 28.

Vlahopoulos S, Zimmer WE, Jenster G, Belaguli NS, Balk SP, Brinkmann AO, Lanz RB, Zoumpourlis VC, Schwartz RJ.

Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene. J. Biol Chem. 2005 Mar 4;280(9):7786-92. Epub 2004 Dec 28.

Barron MR, Belaguli NS, Zhang SX, Trinh M, Iyer D, Merlo X, Lough JW, Parmacek MS, Bruneau BG, Schwartz RJ.

Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes. J Biol Chem. 2005 Mar 25;280(12):11816-28. Epub 2004 Dec 9.

Wang J, Feng XH, Schwartz RJ.

SUMO-1 modification activated GATA4-dependent cardiogenic gene activity. J Biol Chem. 2004 Nov 19;279(47):49091-8. Epub 2004 Aug 27.

Wei L, Taffet GE, Khoury DS, Bo J, Li Y, Yatani A, Delaughter MC, Klevitsky R, Hewett TE, Robbins J, Michael LH, Schneider MD, Entman ML, Schwartz RJ.

Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved. FASEB J. 2004 May;18(7):857-9. Epub 2004 Mar 19.

Brown CO 3rd, Chi X, Garcia-Gras E, Shirai M, Feng XH, Schwartz RJ.

The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J Biol Chem. 2004 Mar 12;279(11):10659-69. Epub 2003 Dec 8.

Chang J, Wei L, Otani T, Youker KA, Entman ML, Schwartz RJ.

Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading. Circulation. 2003 Jul 29;108(4):407-13. Epub 2003 Jul 21.

Chi X, Zhang SX, Yu W, DeMayo FJ, Rosenberg SM, Schwartz RJ.

Expression of Nkx2-5-GFP bacterial artificial chromosome transgenic mice closely resembles endogenous Nkx2-5 gene activity. Genesis. 2003 Apr;35(4):220-6.

Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ.

Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev Cell. 2003 Jan;4(1):107-18.

Rabinovsky ED, Gelir E, Gelir S, Lui H, Kattash M, DeMayo FJ, Shenaq SM, Schwartz RJ.

Targeted expression of IGF-1 transgene to skeletal muscle accelerates muscle and motor neuron regeneration. FASEB J. 2003 Jan;17(1):53-5. Epub 2002 Nov 1.

Sepulveda JL, Vlahopoulos S, Iyer D, Belaguli N, Schwartz RJ.

Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity. J Biol Chem. 2002 Jul 12;277(28):25775-82. Epub 2002 Apr 30

Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider MD, DeMayo FJ, Schwartz RJ.

Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development. 2002 Apr;129(7):1705-14.

Moses KA, DeMayo F, Braun RM, Reecy JL, Schwartz RJ.

Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice. Genesis. 2001 Dec;31(4):176-80.

Li YP, Schwartz RJ.

TNF-alpha regulates early differentiation of C2C12 myoblasts in an autocrine fashion. FASEB J. 2001 Jun;15(8):1413-5.

Wei L, Wang L, Carson JA, Agan JE, Imanaka-Yoshida K, Schwartz RJ.

beta1 integrin and organized actin filaments facilitate cardiomyocyte-specific RhoA-dependent activation of the skeletal alpha-actin promoter.FASEB J. 2001 Mar;15(3):785-96.

Yamada M, Revelli JP, Eichele G, Barron M, Schwartz RJ.

Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Dev Biol. 2000 Dec 1;228(1):95-105.

Schildmeyer LA, Braun R, Taffet G, Debiasi M, Burns AE, Bradley A, Schwartz RJ.

Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouse. FASEB J. 2000 Nov;14(14):2213-20.

Belaguli NS, Sepulveda JL, Nigam V, Charron F, Nemer M, Schwartz RJ.

Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators. Mol Cell Biol. 2000 Oct;20(20):7550-8.

Wei L, Zhou W, Wang L, Schwartz RJ.

beta(1)-integrin and PI 3-kinase regulate RhoA-dependent activation of skeletal alpha-actin promoter in myoblasts. Am J Physiol Heart Circ Physiol. 2000 Jun;278(6):H1736-43.