Weimin He, Publications

Gustafson T.A., He W., Craparo A., Schaub C., & O'Neill T.J.   Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate-1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. (1995)  Molecular and Cellular Biology 15(5): 2500-2508.

He W., O'Neill T.J., & Gustafson T.A.  Distinct modes of interaction of Shc and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. (1995) J. Biological Chemistry 270 (40): 23258-23262.

He W., Craparo A., Zhu Y., O'Neill T.J., Wang L., Pierce J.H., & Gustafson T.A.  Interaction of Insulin   Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor -1 Receptors: Evidence for two distinct phospho-tyrosine-dependent Interaction Domains within IRS-2.  (1996)  J. Biological Chemistry   271(20):11641-11645.

He W., Rose D.W., Olefsky J.M., & Gustafson T. A.  Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains. (1998) J. Biological Chemistry 273(12): 6860-6867.  

Miles P.D.G., Barak Y., He W., Evans R.M. & Olefsky J.M. Improved insulin-sensitivity in mice heterozygous for PPAR-Deficiency. (2000)  J. Clin. Invest   105: 287-292.

Barak Y., Liao D., He W., Ong E.S., Nelson M.C., Olefsky  J.M., Boland R., & Evans R.M.  Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. (2002)   Proc Natl Acad Sci U S A  99:303-308.

Chawla A., Lee CH., Barak Y., He W., Rosenfeld J., Liao D., Han J., Kang H., & Evans R.M.  PPAR is a VLDL sensor in macrophages.  (2003)  Proc Natl Acad Sci U S A 100:1268-1273.

He W., Barak Y., Hevener A., Olson P., Liao D., Le J., Nelson M., Ong E., Olefsky J.M., & Evans  R.M.  Adipose specific PPAR knockout causes insulin resistance in fat and liver but not muscle. (2003)  Proc. Natl. Acad. Sci. U S A 100:15712-15717.

Hevener A., He W.,  Barak Y., Le J.,  Olson P., Wilkes J., Evans  R.M., & Olefsky J.M.  Muscle- specific PPAR gene deletion causes insulin resistance. (2003)  Nat Med   9:1491-1497 (Co-first authors, cover story).

Yang X, Downes M., Yu R.T., Bookout A.L., He W., Straume M., Mangelsdorf D, & Evans R.M. Nuclear Receptor Expression Links the Circadian Clock to Metabolism. (2006) Cell 126 (4):801-10.

Alaynick W.A., Kondo R.P., Xie W., He W., Dufour C.R., Downes M., Jonker J.W., Giles W., Naviaux R.  K., Giguere V., & Evans R.M.  ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the  Postnatal Heart. (2007) Cell Metabolism 6 (7):1-12.

Sears D.D., Hsiao A., Ofrecio J.M., Chapman J, He W., & Olefsky J.M. Selective modulation of promoter recruitment and transcriptional activity of PPARgamma.  (2007)  Bioche. Biophys. Res. Commun. 364 (3):515-521.

Luo W., Cao J., Li J., & He W.   Adipose tissue PPARγ deficiency increases resistance to oxidative stress. Experimental Gerontology (in press).

Zhang C.L., Zou Y., He W., Gage F.H. & Evans R.M. A role for adult TLX-positive neural stem cells in  learning and behavior. Nature (February 21 issue, 2008).

Cao J., Luo W., Li J., Igarashi P., Evans R.M., and He W.   Deletion of PPARγ in kidney results in diabetes insipidus and hydronephrosis. (submitted).

Cao J., Luo W., Davies P., and He W. PPARγ is essential for RXR ligand rexinoid-mediated insulin sensitization in skeletal muscle (in preparation).
 

For other publications, see PubMed (search:  He, W)