Richard H. Finnell, Publications

Pei, L., Zhu, H., Zhu, J., Ren, A., Finnell, R.H., and Li, Z.  2006.  Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial defects and congenital heart defects in China.  Ann. Epidemiol. 16(5):352-356.

Zhu, H., Yang, W., Zhang, J., Shaw, G.M., Lammer, E.J., and Finnell, R.H.  2006. A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida. Mol. Genet. Metab.  87(1):66-70.

Wlodarczyk, B.J., Tang, L.S., Triplett, A., Aleman, F,  and Finnell, R.H. 2006. Spontaneous neural tube defects in Splotch mice supplemented with selected micronutrients.  Toxicol. Appl. Pharmacol. 213:55-63.

Massa, V., Cabrera, R.M., Giavini, E. and  Finnell, R.H.  2006. Myo-inositol enhances teratogenicity of valproic acid in the mouse.  Birth Defects Res. A.  76(3):200-204.

Meador, K.J.,  Baker, G.A., Finnell, R.H., Kalayjian, L.A., Liporace, J.D., Loring, D.W., Pennell, P.B., Smith, J.C., and Wolf, M.C. for the NEAD Study Group. 2006.  Differential Effects of in Utero Exposure to Antiepileptic Drugs:  Serious Adverse Outcomes in Children.  Neurology. 67(3):407-12.

Zhang, J., Zhu, H., Yang, W., Shaw, G.M., Lammer, E.J., and Finnell, R.H.  2006.  Phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphisms and risk of spina bifida. Am. J. Med. Genet. 140(7):785-789.

Zhu, J.H., Ren, A.G., Hao, L., Pei, L.J., Liu, J.M., Zhu, H., Song, L, Finnell, R.H. and Li, Z. 2006. Variable Contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China. Am. J. Med. Genet. 140A:551-557.

Abdelrahim, M., Ariazi, E., Kyounghyun, K., Khan, S., Barhoumi, R., Burghardt, R., Liu, S., Hill, D., Finnell, R., Wlodarczyk, B., Jordan, V.C., and Safe, S.  2006.  3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha.  Cancer. Res. 66:2459-2467.

Wlodarczyk, B.J., Cabrera, R.M. Hill, D.S., Bozinov, D., Zhu, H., and Finnell, R.H. 2006.  Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos.  Neurotoxicology.  27(4):547-557.

Sobol, E., Yagen, B., White, S.H., Papo, O., Wlodarczyk, B.J., Finnell, R.H. and Bialer, M.  2006. Preclinical evaluation of 2,2,3,3-tetramethylcyclopropanecarbonyl-urea, a novel, second generation to valproic acid, antiepileptic drug.  Neuropharmacology 51:933-946.

Ramirez, D., Lammer, E.J., Iovannisci, D., Laurent, C., Finnell, R.H., and Shaw, G.M. 2007.  Maternal smoking during early pregnancy, GSTP1 and EPHX1 variants, and risk of isolated orofacial clefts. Cleft Palate Craniofac J. 44(4):366-373.

Lawrance, A.K., Deng, L., Brody, L.C., Finnell, R.H., Shane, B. and Rozen, R. 2007. Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apc(min/+) mice.  J. Nutr. Bioch. 18(5):305-312.

Blom, H.J., Shaw, G.M., den Heijer, M. and Finnell, R.H.  2006.  Neural tube defects and folate: case far from closed.  Nat. Neuroscience. 7:724-731.

Carmichael, S., Shaw, G.M., Yang, W., Lammer, E.J., Iovannisci, D., Finnell, R.H., Cheng, S.  2006.  Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation.  Am.J. Med. Genet. Nov 15;140(22):2433-40.

Enaw, J.,  Zhu, H., Yang, W., Lu, W., Shaw, G.M., Lammer, E.J., and Finnell, R.H. 2006. CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California Population.  BMC Medicine  4:36.

Shaw, G.M., Pawlowski,L.G., Nelson, V., Zhu, H., Harris, J.A. and Finnell, R.H. 2007.  Infant c677t MTHFR polymorphism and severe mental retardation.  Birth Defects Research, Part A.  79:24-26.

Sobol E, Yagen, B., Lamb, J.G., White, H.S., Wlodarczyk, B.J., Finnell, R.H. and Bialer, M. 2007.  Anticonvulsant activity, neural tube defect induction, mutagenicity and pharmacokinetics of a new potent antiepileptic drug, N-methoxy-2,2,3,3-tetramethylcyclopropane carboxamide. Epilepsy Res. 73:75-84.

Rosenquist, T.H. and Finnell, R.H.  2007.  Another key role for the cardiac neural crest in heart development.  Am. J. Physiol. Heart Circ Physiol. 292(3):H1225-226.

Zhu, H., Wlodarczyk, B., Scott, M., Lu, W., Merriweather, M., Schwartz, R., Gelineau-vanWaes, J., and Finnell, R.H.  2007.  Cardiovascular abnormalities in Folr1 knockout mice and folate rescue. Birth Defects Research, Part A.  79(4):257-268.

Lu, W., Zhu, H., Wen, S., Laurent, C., Shaw, G.M., Lammer, E.J., and Finnell, R.H. 2007.  Screening for novel PAX3 polymorphisms and risks of spina bifida.  Birth Defects Research, Part A.  79:45-49.

Chevrier C, Perret C, Bahuau M, Zhu H, Nelva A, Herman C, Francannet C, Robert-Gnansia E, Finnell RH, Cordier S. 2007.  Fetal and maternal MTHFR C677T genotype, maternal folate intake and the risk of nonsyndromic oral clefts.  Am. J. Med. Genet. 143(3):248-57.

Zhu, H., EbotEnaw, J.O., Ma, C., Shaw, G.M., Lammer, E.J. and Finnell, R.H. 2007. Association between CFL1 gene polymorphisms and spina bifida risk in a California population.   BMC Medical Genetics 8:12.

Rosenquist, T.H., Bennett, G.D., Brauer, P.R., Stewart, M.L., Chaudion, T.R. and Finnell, R.H.  2007.  Microarray analysis of homocysteine-responsive genes in cardiac neural crest cells in vitro. Devel. Dyn. 236(4):1044-1054.

Shaw, G.M., Carmichael, S.L., Laurent, C., Louik, C., Finnell, R.H. and Lammer, E.J. 2007.  Nutrient intakes in women and risks of anophthalmia and microphthalmia in their offspring.  Birth Defects Res. A.  79(10):708-713.

Lawrance, A.K., Wu, Q., Brody, L.C., Finnell, R.H., Shane, B., Rozen, R. Low dietary folate and methylenetetrahydrofolate reductase deficiency alter dUTP/dTTP ratios and DNA methylation in mouse intestine. J. Nutr. Submitted.

Bhattacherjee, V., Wong, L., Henley, A.M., Finnell, R.H., Greene, R.M., Pisano, M.M. Identification of novel proteins that interact with binding protein 1 in embryonic orofacial tissue. Devel. Biol. Submitted.

Gelineau-van Waes, J., Maddox, J., Smith, L., van Waes, M., Wilberding, J., Eudy, J.D., Bauer, L.K., and Finnell, R.H. 2008. Microarray analysis of E9.5 reduced folate carrier knockout embryos reveals altered expression of genes in the cubulin-megalin multi-ligand endocytic receptor complex.  BMC Devel. Biol.  In Press.

Taparia, S., Gelineau-van Waes, J., Rosenquist, T.H. and Finnell, R.H.  2007. Importance of Folate-Homocysteine Homeostasis During Early Embryonic Development.  Clinical Chemistry and Laboratory Medicine.  45:1717-1727.

Shimshoni, J., Bialer, M., Wlodarczyk, B., Finnell, R., and Yagen, B. 2007.  Potent anticonvulsant urea derivatives of constitutional isomers of Valproic Acid. J. Med. Chem.  50(25):6419-6427.

Harden, C.L., Hopp, J., Ting, T.Y.,  French, J., Pennell, P.B., Hovinga, C.A., Meador, K.J., Koppel, B.S., Hauser, W.A., Thurman, D., Kaplan, P.W., Robinson, J.N., Wiebe, S., Gidal, B., Wilner, A.N., Vasquez,B.,  Holmes, L., Krumholz, A., Finnell, R.H., Shafer, P.O.  2008.  (Reassessment) Practice Parameter: Management issues for women with epilepsy-focus on pregnancy (an evidence-based review).  Neurology. In Press.

Wong, R.L., Wlodarczyk, B.J., Min, K.S., Scott, M.L., Kartiko, S., Yu, W., Merriweather, M.Y., Vogel, P., Zambrowicz, B.P. and Finnell, R.H.  2008. Endogenous FKBP8 activity inhibits cell death and establishes dorso-ventral patterning in the posterior neural tube.  Hum. Mol. Genet.  In Press.

Gelineau-van Waes, J., Heller, S., Brauer, L.K., Wilberding, J., Maddox, J., Aleman, F., Rosenquist, T.H. and Finnell, R.H.  Early embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation.  Birth Defects Research. A.  Submitted.

Taparia, S., Low, P., and Finnell, R.H.  A fluorimetric approach to study transport of folic acid in to a human trophoblastic bewo cell line.  Placenta.  Submitted.

Zhu, H., Cabrera, R.M., Wlodarczyk, B., Bozinov, D., Schwartz, R.J. and Finnell, R.H. 2007. Microarray analysis of differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity.  BMC Dev Biol. 2007 Nov 20;7(1):128.

Kappen, C., Neubüser, A., Balling, R., Finnell, R.  2007. Molecular basis for skeletal variation: insights from developmental genetic studies in mice. Birth Defects Res. B. 80(6):425-450.

For other publications, see PubMed (search:  Finnell, RH)