Laura E. Mitchell Publications

Haddow JE, Hill LE, Kloza EM, Thanhouser D. Neural tube defects after gastric bypass. Lancet i:1330, 1986.

Kloza EM, Hill LE, Haddow JE. Open fetal malformations in incorrectly dated pregnancies with initially low maternal serum alpha-fetoprotein results. Lancet ii:275-276, 1987.

Haddow JE, Hill LE, Palomaki GE, Knight GJ: Very low versus undetectable maternal serum alpha-fetoprotein values and fetal death. Prenat. Diag. 7:401- 406, 1987.

Palomaki GE, Hill LE, Knight GJ, Haddow JE: Second trimester maternal serum alpha-fetoprotein levels in pregnancies associated with gastroschisis and omphalocele. Obstet. Gynecol. 71:906-909, 1988.

New England Regional Genetics Group Prenatal Collaborative Study of Down Syndrome Screening. Combining maternal serum alpha-fetoprotein measurements and age to screen for Down syndrome in women under age 35. Am J Obstet Gynecol 160:571-581, 1989 (participation sited by not by authorship).

Mitchell LE, Bracken MB: Reproductive versus chronologic age as a predictor of low birth weight, preterm delivery and intra-uterine growth retardation in primiparous women. Ann. Hum. Biol. 17:377-386, 1990.

Mitchell LE, Risch N: Mode of inheritance of non-syndromic cleft lip with or without cleft palate: A reanalysis. Am. J. Hum. Genet. 51:323-332, 1992.

Mitchell LE, Risch N: Correlates of genetic risk for non-syndromic cleft lip with or without cleft palate. Clin. Genet. 43:255-260, 1993.

Nirmala A, Mitchell LE, Rice T, Reddy PC, Rao DC: Assessment of adiposity in an Indian population: Familial correlations. Genet. Epidemiol. 10:133-143, 1993.

Mitchell LE, Nirmala A, Rice T, Reddy PC, Rao DC: The impact of energy intake and energy expenditure of activity on the familial transmission of adiposity in an Indian population. Am. J. Hum. Biol. 5:331-339, 1993.

Mitchell LE, Risch N: The genetics of infantile hypertrophic pyloric stenosis: A reanalysis. Am. J. Dis. Child. 147:1203-1211, 1993.

Rice T, Sprecher DL, Borecki IB, Mitchell LE, Laskarzewski PM, Rao DC: The Cincinnati Myocardial Infarction and Hormone (CIMIH) family study:  Familial resemblance for dehydroepiandrosterone sulfate in control and myocardial infarction families. Metabolism 42:1284-1290, 1993.

Rice T, Sprecher D, Borecki IB, Mitchell LE, Laskarzewski PM, Rao DC: The Cincinnati Myocardial Infarction and Hormone (CIMIH) family study: Family resemblance for testosterone in random and MI families. Am. J. Med. Genet. 47:542-549, 1993.

Mitchell LE, Nirmala A, Rice T, Reddy PC, Rao DC: Commingling analysis of adiposity in an Indian population. Int. J. Obesit. 18:1-8, 1994.

Mitchell LE, Sprecher DL, Borecki IB, Rice T, Laskarzewski PM, Rao DC:  Evidence for an association between dehydroepiandrosterone sulfate and non- fatal, premature myocardial infarction in males. Circulation 89:89-93, 1994.

Mitchell LE, Healey SC, Chenevix-Trench G: Evidence for an association between non-syndromic cleft lip with or without cleft palate and a gene located on the long are of chromosome 4. Am. J. Hum. Genet. 57:1130-1136, 1995.

Mitchell LE: Sequential analysis of marker data for a rare oligogenic disease.  Genet. Epidmiol. 12:647-651, 1995.

Mitchell LE, Christensen K: Analysis of the recurrence patterns for non- syndromic cleft lip with or without cleft palate in the families of 3,073 Danish probands. Am. J. Med. Genet. 61:371-376, 1995.

Christensen K, Mitchell LE: Familial recurrence-pattern analysis of non- syndromic isolated cleft palate - a Danish registry study. Am. J. Hum. Genet. 58:182-190, 1996.

Kane AA, Mitchell LE, Craven KP, Marsh JL. Observations on a recent increase in plagiocephaly without synostosis. Pediatrics 97:877-885, 1996.

Mitchell LE, Duffy DL, Duffy P, Bellingham G, Martin NG. Genetic effects on variation in red blood cell folate in adults: implications for the familial aggregation of neural tube defects. Am. J. Hum. Genet. 60:433-438, 1997.

Mitchell LE. Transforming growth factor alpha and nonsyndromic cleft lip with or without cleft palate: a reappraisal. Genet. Epidemiol. 14:231-240, 1997.

Driscoll DA, Emanuel BS, Mitchell LE, Budarf ML. PCR assay for screening patients at risk for 22q11.2 deletion. Genet. Test. 1:109-113, 1997.

Mitchell LE. Differentiating between fetal and maternal genotypic effects using the transmission test for linkage disequilibrium. Am. J. Hum. Genet. 60:1006- 1007, 1997.

Goldmuntz E, Clark BJ, Mitchell LE, Jawad A, Cuneo BF, McDonald-McGinn D, Chien P, Feuer J, Zackai EH, Emanuel BS, Driscoll DA. Frequency of 22q11 deletions in patients with conotruncal defects. J Am Coll Cardiol 32: 492-498, 1998.

Mitchell, LE. The relationship between case-control studies and the transmission disequilibrium test. Genet Epidemiol 19:193-201, 2000.

Mitchell LE, Murray JC, O'Brien S, Christensen K. Evaluation of two putative susceptibility loci for oral clefts in the Danish population.  Am J Epidemiol. 153:1007-1015, 2001.

Underkoffler LA, Mitchell LE, Localio AR, Marchegiani SM, Morabito, Collins JN, Oakey RJ.  Molecular analysis of nondisjunction in mice heterozygous for a Robertsonian translocation.  Genetics 161:1219-1224, 2002.

Doolin M-T, Barbaux S, McDonnell M, Hoess K, Whitehead AS, Mitchell LE.  Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida.  American Journal of Human Genetics 71:1222-1226, 2002.

Mitchell LE, Murray JC, O’Brien S, Christensen, K.  Retinoic acid receptor alpha gene variants, multivitamin use and liver intake as risk factors for oral clefts: a population-based case-control study in Denmark, 1991-1994.  Am J Epidemiol, 158:69-76, 2003.

Brown KS, Kluijtmans LAJ, Young IS, Woodside J, Yarnell JWG, McMaster D, Murray L, Evans AE, Boreham CA, McNulty H, Strain JJ, Mitchell LE, Whitehead AS.  Genetic evidence that nitric oxide modulates homocysteine.  The NOS3 894TT genotype is a risk factor for hyperhomocystinemia.  Arterioscler Thromb Vasc Biol, 23:1014-1020, 2003.

Brown KS, Kluijtmans, LAJ, Young IS, McNulty H, Mitchell LE, Yarnell JWG, Woodside JV, Boreham CA, McMaster D, Murray L, Strain JJ, Whitehead AS.  The thymidylate sythase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjects.  Human Genetics, 114:182-185, 2004.

Brown KS, Cook M, Hoess K, Whitehead AS, Mitchell LE.  Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus.  Birth Defects Research (Part A) 70:101-106, 2004.

Brown KS, Kluijtmans LAJ, Young IS, Murray L, McMaster D, Woodside JV, Yarnell JWG, Boreham CA, McNulty H, Strain JJ, Mitchell LE, Whitehead AS.  The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine.  Atherosclerosis, 174:315-322, 2004.

Jensen LE, Wall AM, Cook M, Hoess K, Thorn CF, Whitehead AS, Mitchell LE.  A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida.  Birth Defects Research (Part A), 70:396-399, 2004.

Spiegelstein O, Mitchell, LE, Merriweather MY, Wicker NJ, Zhang Q, Lammer EJ, Finnell RH.  Embryonic development of folate binding protein-1 (Folbp1) knockout mice: effects of the chemical form, dose, and timing of maternal folate supplementation.  Developmental Dynamics 231:221-231, 2004.

Jensen LE, Barbaux S, Hoess K, Fraterman S, Whitehead AS, Mitchell LE.  The human T locus and spina bifida risk.  Human Genetics, 115:475-482, 2004.

Underkoffler LA, Mitchell LE, Abdulali ZS, Collins JN, Oakey RJ.  Transmission ratio distortion in offspring of mouse heterozygous carriers of a (7.18) Robertsonian translocation.  Genetics, 169:843-848, 2005.

Masilla MA, Kimani J, Mitchell LE, Christensen K, Boomsma DI, Daack-Hirsch S, Nepomucena B, Wyszynski DF, Felix TM, Martin NG, Murray JC.  Discordant MZ twins with cleft lip and palate: a model for identifying genes in complex traits.  Twin Research and Human Genetics 8:29-46, 2005.

Jensen LE, Hoess K, Whitehead AS, Mitchell LE.  The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida.  Birth Defects Research Part A 73:512-516, 2005.

Etheredge AJ, Christensen K, del Junco D, Murray JC, Mitchell LE.  Evaluation of two methods for assessing gene-environment interactions using data from the Danish case-control study of facial clefts.  Birth Defects Research (A) 73:541-546, 2005.

Mitchell LE, Weinberg CR.  Evaluation of offspring and maternal genetic effects on disease risk using a family-based approach: the “Pent” design.  American Journal of Epidemiology.  162:676-685, 2005.

Rampersaud E, Bassuk AG, Enterline DS, Siegel DG, Melvin EC, Aben J, Allen J, Alysworth A, Brei T, Bodhurtha J, Buran C, Floyd LE, Hammock P, Iskandar B, Ito J, Kessler JA, Lasarsky N, Mack P, Mackey J, McLone D, Meeropol E, Mehltrtter L, Mitchell LE, Oakes J, Nye JS, Powell C, Sawin K, Stevenson R, Walker M, West SG, Worley G, Gilbert JR, Speer MC.  Whole genome-wide linkage screen for neural tube defects reveals regions of interest on chromosomes 7 and 10.  Journal of Medical Genetics 42:940-946, 2005.

Jensen LE, Etheredge AJ, Brown KS, Mitchell LE, Whitehead AS.  Maternal genotype for the monocyte chemoattractant protein 1 A(-2518)G promoter polymorphism is associated with the risk of spina bifida in offspring.  American Journal of Medical Genetics 140:1114-1118, 2006.

Jensen LE, Hoess K, Mitchell LE, Whitehead AS.  Loss of function polymorphisms in NAT1 protect against spina bifida.  Human Genetics 120:52-57, 2006.

Driscoll DA, Boland T, Emanuel BS, Kirschner RE, LaRossa D, Manson J, McDonald-McGinn, Randall P, Solot C, Zackai E, Mitchell, LE.  Evaluation of potential modifiers of the palatal phenotype in the 22q11 deletion syndrome.  Cleft Palate Craniofacial Journal 43:435-441, 2006.

Shu W, Ethen M, Langlois PH, Mitchell LE.  Prevalence of encephalocele in Texas, 1999 2002.  American Journal of Medical Genetics 143A:2150-2155, 2007.

Stanislawska-Sachadyn A, Woodside JV, Brown KS, Young IS, Murray L, McNulty H, Strain JJ, Boreham CA, Scott JM, Whitehead AS, Mitchell LE.  Sex differences in the determinants of momocysteine Concentrations.  Molecular Genetics and Metabolism, in press.

Stanislawska-Sachadyn A, Brown KS, Mitchell LE, Woodside JV,, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS.  An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women.  Human Genetics, in press.

Non-refereed Papers (including letters)

Mitchell LE. Interpreting the evidence for an association between the retinoic acid receptor locus and nonsyndromic cleft lip with or without cleft palate. J. Med. Genet. 31:425, 1994.

Mitchell LE, Christensen K. Evaluation of family history data for Danish twins with nonsyndromic cleft lip with or without cleft palate. Am. J. Med. Genet.  72:120-121, 1997.

Treloer SA, Macones G, Mitchell LE, Martin NG. Genetic influences on premature paturition in an Australian twin sample. Twin Research 3:80-82, 2000.

Weinberg CR, Mitchell, LE.  Letter regarding “Parental genotypes in the risk of complex diseases”.  American Journal of Human Genetics 71:1239-1240, 2002.

For other publications, see PubMed (search:  Mitchell, LE)