Five Most Significant Publications Prior to 2011

Liu, M., Chen, T.-Y., Ahamed, B., Li, J. and Yau, K.-Y.  1994.  Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel.   Science   266, 1348-1354. (Research Article)

Liu, M., and Simon, M.I.  1996.  Regulation by cAMP-dependent protein kinase of a G-protein mediated phospholipase C.   Nature   382, 82-87 (1996).

Stafford, L.J., Xia, C., Ma, W., Cai, Y., and Liu, M. (2002) Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein coupled receptor. Cancer Res.62: 5399-5404.

Hsu, Y-C., Chern, J.J., Cai, Y., Liu, M., and Choi, K.W. (2007) Drosophila homolog of TCTP regulates cell growth and proliferation through regulation of dRheb GTPase. Nature 445 (7129), 785-788.

Weng, J., Cheng, X., Luo, J., Jin, C., Zhou, X., Qu, J., Tong, L., Ai, D., Li, D., Wang, J., Amendt, B., Martin, J.F., and Liu, M. 2008. Deletion of G-protein coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down regulation of Pitx2. Proc. Natl. Acad. Sci. 105, 6081-6086.

Publications 2011 

Cho, S.G., Wang, Y., Rodriguez, M., Tan, K., Li, D., and Liu, M.*  2011.  Kiss1 G protein-coupled receptor (Gpr54) haploinsufficiency delays breast tumor initiation, progression and lung metastasis. Cancer Research 2011 Oct 15; 71(20)6535-46.  Epub 2011 August 18.  PMID: 21852382. (Cover story)

Pang, X., Zhang, L., Lai, L., Chen, J., Yi, Z., Zhang, J., Qu, W., Aggarwal, B.B., and Liu, M.* 2011.  1’-Acetoxychavicol Acetate Suppresses Angiogenesis- Mediated Human Prostate Tumor Growth by Targeting VEGF-mediated Src-FAK Signaling Pathway.  Carcinogenesis. 2011 Jun; 32(6):904-12. Epub 2011 Mar 22. PMID: 21427164.

Pang, X., Chen, J., Wang, J., Lu, B., Wu, Y., Yi, Z., Qu, W., and Liu, M.*  2011.  Gossypol, a Natural BH3 Mimetic, Suppresses Prostate Tumor Growth by Inhibiting VEGF Receptor 2-Mediated Angiogenesis. Molecular Cancer Therapeutics. 2011 Mar 3. PMID: 21372225.

Mitchell DC, Bryan BA, Liu L, Hu XH, Huang XQ, Ji WK, Chen PC, Hu WF, Liu JP, Zhang J, Liu M, Li DW.  2011.  GEFT, A Rho family guanine nucleotide exchange factor, regulates lens differentiation through a Rac1-mediated mechanism. Curr Mol Med. 2011 Aug; 11(6):465-80. IF= 5.212

Dong A, Fang Y, Zhang L, Xie J, Wu X, Zhang L, Lian X, Chen Y, Luo J, Liu M.* 2011. Caffeic acid 3,4-dihydroxy-phenethyl ester induces cancer cell senescence by suppressing twist expression.  J Pharmacol Exp Ther. 2011 Oct; 339(1):238-47. Epub 2011 Jul 15.  PMID: 21765040

Lai L, Liu J, Zhai D, Lin Q, He L, Dong Y, Zhang J, Lu B, Chen Y, Yi Z, Liu M.*  2011.  Plumbagin Inhibits Tumor Angiogenesis and Tumor Growth through VEGFR2-mediated Ras Signaling Pathway.  Br J Pharmacol. 2011 Jun 9. doi: 10.1111/j.1476-5381.2011.01532.x. [Epub ahead of print].  PMID: 21658027.

Pang X, Wu Y, Wu Y, Lu B, Chen J, Wang J, Yi Z, Qu W, Liu M.* 2011.  (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.  Mol Cancer Ther. 2011 May; 10(5):795-805. Epub 2011 Mar 3. PMID: 21372226

Yu W, Qiu Z, Gao N, Wang L, Cui H, Qian Y, Jiang L, Luo J, Yi Z, Lu H, Li D, and Liu M.* 2011. PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop. Nucleic Acids Res. 2011 Mar; 39(6):2234-48. Epub 2010 Nov 21. PMID: 21097889

Cai Z, Sanchez A, Shi Z, Zhang T, Liu M, Zhang D.  2011.  Activation of Toll-like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth. Cancer Research 2011 Apr 1; 71(7):2466-75. Epub 2011 Mar 22.PMID:21427357.

Wu Y, He L, Zhang L, Chen J, Yi Z, Zhang J, Liu M, Pang X. 2011. Anacardic Acid (6-Pentadecylsalicylic Acid) Inhibits Tumor Angiogenesis by Targeting Src/FAK/Rho GTPases Signaling Pathway.  J Pharmacol Exp Ther. 2011 Nov; 339(2):403-11. Epub 2011 Aug 9.  PMID: 21828260

Zhang Z, Wang Z, Ren H, Yue M, Huang K, Gu H, Liu M, Du B, Qian M.  2011.  P2Y6 Agonist Uridine 5'-Diphosphate Promotes Host Defense against Bacterial Infection via Monocyte Chemoattractant Protein-1-Mediated Monocytes/ Macrophages Recruitment.  J. Immunol. 2011 Mar 28.PMID: 21444765

Kuang L, Wang L, Wang Q, Zhao Q, Du B, Li D, Luo J, Liu M, Hou A, Qian M.  2011. Cudratricusxanthone G inhibits human colorectal carcinoma cell invasion by MMP-2 down-regulation through suppressing activator protein-1 activity.  Biochem Pharmacol. 2011 Mar 4. PMID:21377450

Jia Y, Jing J, Bai Y, Li Z, Liu L, Luo J, Liu M, Chen H. Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-regulation of JAK-STAT and NF-<kappa>B Signaling Pathways. PLoS One. 2011; 6(10):e27006. Epub 2011 Oct 31. PMID： 22066025

Chen G, Yin K, Shi L, Fang Y, Qi Y, Li P, Luo J, He B, Liu M, Shi T. 2011. Comparative analysis of human protein-coding and noncoding RNAs between brain and 10 mixed cell lines by RNA-Seq.  PLoS One 2011; 6(11):e28318. Epub 2011 Nov 30. PMID: 22140575

Chen G, Li R, Shi L, Qi J, Hu P, Luo J, Liu M, Shi T.  2011.  Revealing the missing expressed genes beyond the human reference genome by RNA-Seq.  BMC Genomics 2011 Dec 2; 12(1):590.  PMID: 22133125

Chen L, Wu H, Pochynyuk OM, Reisenauer MR, Zhang Z, Huang L, Zaika OL, Mamenko M, Zhang W, Zhou Q, Liu M, Xia Y, Zhang W. 2011.  Af17 deficiency increases sodium excretion and decreases blood pressure.  J Am Soc Nephrol. 2011 Jun; 22(6):1076-86. Epub 2011 May 5.  PMID: 21546577.

Zhang X, Song Y, Wu Y, Dong Y, Lai L, Zhang J, Lu B, Dai F, He L, Liu M, Yi Z.  2011.  Indirubin inhibits tumor growth by anti-tumor angiogenesis through blocking VEGFR2 mediated JAK/STAT3 signaling in endothelial cell. Int J   Cancer. 2011 Jan 4. [Epub ahead of print] PMID: 21207415

Yang J, Fan H, Hao J, Ren Y, Chen L, Li G, Xie R, Yang Y, Qian K, Liu M. 2011.  Amelioration of acute graft-versus-host disease by adoptive transfer of ex vivo expanded human cord blood CD4+CD25+ forkhead box protein 3+ regulatory T cells is associated with the polarization of Treg/Th17 balance in a mouse model.  Transfusion. 2011 Nov 21. doi: 10.1111/j.1537-2995.2011.03448.x. [Epub ahead of print].  PMID: 22098312

Teng Y, Liu M, Cowell JK.  2011.  Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells. Int J Cancer. 2011 Dec 15; 129(12):2825-35. doi: 10.1002/ijc.25964. Epub 2011 May 5. PMID: 21544801

Pan X, Han H, Wang L, Yang L, Li R, Li Z, Liu J, Zhao Q, Qian M, Liu M, Du B.  2011.  Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway. Cancer Lett. 2011 Dec 27; 313(2):181-91. Epub 2011 Sep 10.  PMID: 21959111

Sung B, Cho SG, Liu M, and Aggarwal BB.   2011.  Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of RANKL signaling.  Int J Cancer. 2010 Dec 17..PMID: 21170936

Park, B., Sung, B., Yadav, V., Cho, S.G., Liu, M., and Aggarwal, B.B. 2011.  Acetyl-11-keto-β-Boswellic Acid Suppresses Invasion of Pancreatic Cancer Cells through the Downregulation of CXCR4 Chemokine Receptor expression.  Int J Cancer 2011 Jul 1; 129(1):23-33. doi: 10.1002/ijc.25966. Epub 2011 Mar 29. PMID: 21448932

Chen J, Li T, Wu Y, He L, Zhang L, Shi T, Yi Z, Liu M, Pang X.  2011.  Prognostic significance of vascular endothelial growth factor expression in gastric carcinoma: a meta-analysis. J Cancer Res Clin Oncol. 2011 Dec; 137(12):1799-812. Epub 2011 Sep 15.  PMID: 21918901

He L, Wu Y, Lin L, Wang J, Wu Y, Chen Y, Yi Z, Liu M, and Pang X.   2011.  Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway. Cancer Sci. 2011 Jan; 102(1): 219-25.PMID: 21087351 

Publications 2012

Cho SG, Li D, Tan K, Siwko SK, Liu M. 2012. KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis.  Cancer Metastasis Rev. 2012 Dec;31(3-4):585-91. doi: 10.1007/s10555-012-9367-7.  PMID: 22692479 

Wang J, Li X, Ke Y, Lu Y, Wang F, Fan N, Sun H, Zhang H, Liu R, Yang J, Ye L, Liu M, Ning G. 2012. GPR48 increases mineralocorticoid receptor gene expression. J Am Soc Nephrol. 2012 Feb;23(2):281-93. doi: 10.1681/ASN.2011040351. PMID: 22135314 

Chen J, Wang J, Lin L, He L, Wu Y, Zhang L, Yi Z, Chen Y, Pang X, Liu M. 2012. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012 Feb;11(2):277-87. doi: 10.1158/1535-7163.MCT-11-0648.  PMID: 22203730 

Xu J, Li Z, Luo J, Yang F, Liu T, Liu M, Qiu W, Tang J. 2012. Synthesis and Biological Evaluation of Heterocyclic Ring-fused Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption. J Med Chem. 2012 Apr 12; 55(7):3122-34. doi: 10.1021/jm201540h.  PMID: 22435650 

Wang Y, Chen Y, Wang J, Chen J, Aggarwal BB, Pang X, Liu M. 2012. Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor. Curr Mol Med. 2012 Feb; 12(2):153- 62. 

Tang XL, Wang Y, Li DL, Luo J, Liu MY. 2012. Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets. Acta Pharmacol Sin. 2012 Mar;33(3):363-71. doi: 10.1038/aps.2011.210. Epub 2012 Feb 27. PMID: 22367282  

Fan H, Yang J, Hao J, Ren Y, Chen L, Li G, Xie R, Yang Y, Gao F, Liu M. 2012. Comparative Study of Regulatory T Cells Expanded Ex Vivo from Cord Blood and Adult Peripheral Blood. Immunology. 2012 Jun;136(2):218-30. doi: 10.1111/j.1365-2567.2012.03573.x. PMID: 22348606 

Yang J, Fan H, Hao J, Ren Y, Chen L, Li G, Xie R, Yang Y, Qian K, Liu M. 2012.  Amelioration of acute graft-versus-host disease by adoptive transfer of ex vivo expanded human cord blood CD4+CD25+ forkhead box protein 3+ regulatory T cells is associated with the polarization of Treg/Th17 balance in a mouse model.  Transfusion. 2012 Jun;52(6):1333-47. doi: 10.1111/j.1537-2995.2011.03448.x. PMID: 22098312 

Wu X, Li Z, Yang Z, Zheng C, Jing J, Chen Y, Ye X, Lian X, Qiu W, Yang F, Tang J, Xiao J, Liu M, Luo J. 2012. CADPE suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of MAPK/AP-1 and Ca(2+) -NFAT signaling pathways. J Bone Miner Res. 2012 Jun;27(6):1298-1308. doi: 10.1002/jbmr.1576.  PMID: 22337253. 

Dai F, Chen Y, Song Y, Huang L, Zhai D, Dong Y, Lai L, Zhang T, Li D, Pang X, Liu M, Yi Z. 2012.  A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells.  PLoS One. 2012;7(12):e52162. doi: 10.1371/journal.pone.0052162. Epub 2012 Dec 27. PMID: 23300602 

Zhao Q, Qian Y, Li R, Tan B, Han H, Liu M, Qian M, Du B. 2012.  Norcantharidin facilitates LPS-mediated immune responses by up-regulation of AKT/NF-κB signaling in macrophages. PLoS One. 2012;7(9):e44956. doi: 10.1371/journal.pone.0044956. Epub 2012 Sep 11. PMID: 22984593 

Zhang T, Li J, Dong Y, Zhai D, Lai L, Dai F, Deng H, Chen Y, Liu M, Yi Z. 2012. Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion.  Breast Cancer Res Treat. 2012 Sep;135(2):445-58. doi: 10.1007/s10549-012-2175-5. Epub 2012 Jul 28. PMID: 22842972 

Lai L, Liu J, Zhai D, Lin Q, He L, Dong Y, Zhang J, Lu B, Chen Y, Yi Z, Liu M. 2012.  Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2.  Br J Pharmacol. 2012 Feb;165(4b):1084-96. doi: 10.1111/j.1476-5381.2011.01532.x.  PMID: 21658027 

Song Y, Dai F, Zhai D, Dong Y, Zhang J, Lu B, Luo J, Liu M, Yi Z. 2012.  Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways.  Angiogenesis. 2012 Sep;15(3):421-32. doi: 10.1007/s10456-012-9270-4. Epub 2012 Apr 11.  PMID: 22669534 

Li Z, Xiao J, Wu X, Li W, Yang Z, Xie J, Xu L, Cai X, Lin Z, Guo W, Luo J, Liu M. 2012.  Plumbagin Inhibits Breast Tumor Bone Metastasis and Osteolysis by Modulating the Tumor-Bone Microenvironment.  Curr Mol Med. 2012 Sep; 12(8):967-81. [Epub ahead of print].  PMID: 22574935 

Publications 2013

Fang Y, Chen Y, Yu L, Zheng C, Qi Y, Li Z, Yang Z, Zhang Y, Shi T, Luo J, Liu M.  2013.  Inhibition of Breast Cancer Metastases by a Novel Inhibitor of TGFβ Receptor 1. J Natl Cancer Inst. 2013 Jan 2;105(1):47-58. doi: 10.1093/jnci/djs485. Epub 2012 Nov 24. PMID:23178439

Wu H, Chen L, Zhang X, Zhou Q, Li JM, Berger S, Borok Z, Zhou B, Xiao Z, Yin H, Liu M, Wang Y, Jin J, Blackburn MR, Xia Y, Zhang W.  2013.  Aqp5 is a new transcriptional target of dot1a and a regulator of aqp2.  PLoS One. 2013;8(1):e53342. Epub 2013 Jan 10.  PMID: 23326416