Center for Environmental and Genetic Medicine
Member of the GSBS Faculty
Education and Post-Graduate Training
Rhead, W.J., B.A. Amendt, K.S. Fritchman and S.J. Felts. 1983. Dicarboxylic aciduria: deficient (1-14C) octanoate oxidation and medium chain acyl-CoA dehydrogenase activity in fibroblasts. Science 221:73.
Amendt, B.A. and W.J. Rhead. 1983. Catalytic defect of medium chain acyl-coenzyme A dehydrogenase deficiency. J. Clin. Invest. 76:963-969.
Rhead, W.J. and B.A. Amendt. 1984. Electron transferring flavoprotein deficiency in the multiple acyl-CoA dehydrogenation disorders, glutaric aciduria type II and ethylmalonic adipic aciduria. J. Inherited Metab. Dis.,7, Suppl. 2:99.
Amendt, B.A. and W.J. Rhead. 1986. The multiple acyl-coenzyme A dehydrogenase disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria. J. Clin. Invest. 78:205-213.
Amendt, B.A., C. Green, L. Sweetman, J. Cloherty, V. Shih, A. Moon, L. Teel and W.J. Rhead. 1987. Short-chain acyl-coenzyme A dehydrogenase deficiency, clinical and biochemical studies in two patients. J. Clin. Invest. 79:1303-1309.
Amendt, B.A., A. Moon, L. Teel and W.J. Rhead. 1988. Long-chain acyl-coenzyme A dehydrogenase deficiency: biochemical studies in fibroblasts from three patients. Ped. Res. 23, No.6:603.
Wood, P.A., B.A. Amendt, W.J. Rhead, D.S. Millington, F. Inoue and D. Armstrong. 1989. Short-chain acyl-coenzyme A dehydrogenase deficiency in mice. Ped. Res. 25, No.1:38.
Roettger, V., T. Marshall, B.A. Amendt and W.J. Rhead. 1992. Multiple acyl-coenzyme A dehydrogenation disorders (MAD) responsive to riboflavin: biochemical studies in fibroblasts. Prog. Clin. Biol. Res. 375:317.
Amendt, B.A., C. Reece, P.A. Wood and W.J. Rhead. 1992. Short-chain acyl-coenzyme A dehydrogenase activity and antigen are absent in the BALB/c ByJ mouse. Ped. Res. 31, No.6:552.
Roettger, V., T. Marshall, B.A. Amendt and W.J. Rhead. 1993. Multiple acyl-coenzyme A dehydrogenation disorder responsive to riboflavin: Substrate oxidation, flavin metabolism and flavoenzyme activities in fibroblasts. Ped. Res. 33, No.2:129.
Amendt, B.A., D. Hesslein, Lung-Ji Chang and C.M. Stoltzfus. 1994. Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of the human immunodeficiency virus type I. Mol. Cell. Biol. 14:3960-3970.
Brown, W.R., I. Kacskovics, B.A. Amendt, N.B. Blackmore, M. Rothschild, R. Shinde and J. E. Butler. 1995. The hinge deletion allelic variant of porcine IgA results from mutation of the splice acceptor site in the first Ca intron. J. Immunology, 154:3836-3842.
Amendt, B.A., S.S. Simpson and C.M. Stoltzfus. 1995. Inhibition of RNA splicing at the Rous sarcoma virus src 3' splice site is mediated by an interaction between a negative cis element and a chicken embryo fibroblast nuclear factor. J. Virology., 69:5068-5076.
Amendt, B.A., Z. Si and C.M. Stoltzfus, 1995. Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tat-rev exon 3: Evidence for inhibition mediated by cellular factors. Mol. Cell. Biol., 15:4606-4615.
Si, Zhi-hai, B.A. Amendt and C.M. Stoltzfus, 1997. Splicing efficiency of human immunodeficiency virus type 1 tat RNA is determined by both a suboptimal 3' splice site and a 10 nucleotide exon splicing silencer element located within tat exon 2. Nuc. Acids Res., 25:861-867.
Zhu, Y., T. Pe'ery, J. Peng, Y. Ramanathan, N. Marshall, T. Marshall, B.A. Amendt, M. Mathews and D. Price, 1997. Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro. Genes and Dev., 11:2622
Amendt, B.A., L.B. Sutherland and A.F. Russo, 1998. The Molecular Basis of Rieger Syndrome: Analysis of Pitx2 Homeodomain Protein Activities. J.Biol. Chem., 273:20066-20072.
Amendt, B.A., L.B. Sutherland and A.F. Russo, 1999. Transcriptional Antagonism between Hmx1 and Nkx2.5 for a Shared DNA Binding Site. J. Biol. Chem., 274:11635-11642.
Amendt, B.A., L.B. Sutherland and A.F. Russo, 1999. Multifunctional Role of the Pitx2 Homeodomain Protein C-Terminal Tail. Mol. Cell. Biol., 19:7001-7010.
Semina E.V., C. Funkhauser, P. Bitoun, W.L.M. Alward, S. Daack-Hirsh, B.A. Amendt, B. Ludwig and J.C. Murray, 1999. Spectrum and frequency of PITX2/RIEG mutations in patients with Rieger syndrome and related ocular anomalies. Am. J. Hum. Genet. 65:Suppl.A490.
Amendt, B.A., E.V. Semina and W.L.M. Alward, 2000. Rieger Syndrome: A Clinical, Molecular and Biochemical Analysis. An invited review for Cell. Mol. Life Sci., 57:1652-1666.
Hjalt, T.A., E.V. Semina, B.A. Amendt and J.C Murray, 2000. The PITX2 Protein In Mouse Development. Developmental Dynamics, 218:195-200.
Hjalt, T.A., B.A. Amendt and J.C. Murray, 2000. PITX2 regulates PLOD gene expression: implications for the pathology of Rieger syndrome. J. Cell Biol., 152:545-552
Green, P.D., T.A. Hjalt, L.B. Sutherland, B.L. Thomas, P.T. Sharpe, M.L. Snead, J.C. Murray, A.F. Russo, and B.A. Amendt, 2001. Antagonistic Regulation of Dlx2 Expression by PITX2 and Msx2: Implications for Tooth Development. Gene Expr., 9:265-281.
Saadi, I., E.V. Semina, B.A. Amendt, D.J. Harris, K.P. Murphy, J.C. Murray and A.F. Russo, 2001. Identification of a Dominant Negative Homeodomain Mutation in Rieger Syndrome. J. Biol. Chem., 276:23034-23041.
Espinoza, H.M., C. Cox, E.V. Semina and B.A. Amendt, 2002. A Molecular Basis for Differential Developmental Anomalies in Axenfeld-Rieger Syndrome. Hum. Mol. Genet., 11:743-753.
Cox, C., H.M. Espinoza, B. McWilliams, K. Chappell, L. Morton, T.A. Hjalt, E.V. Semina and B.A. Amendt, 2002. Differential Regulation of Gene Expression by PITX2 Isoforms. J. Biol. Chem., 277:25001-25010.
Shaw, P.A., X. Zhang, A.F. Russo, B.A. Amendt, S. Henderson, and V. Williiams, 2003. Homeobox Protein, Hmx, in Postnatally Developing Rat Submandibular Glands. J Histochem Cytochem. 51:385-96.
Ganga, M., L. H. M. Espinoza, C.J. Cox, L. Morton, T.A. Hjalt, Y. Lee, and B.A. Amendt, 2003. PITX2 Isoform-specific Regulation of Atrial Natriuretic Factor Expression: Synergism and Repression with Nkx2.5. J. Biol. Chem., 278:22437-22445.
Trembath D.G., E.V. Semina, D. H. Jones, S. Patil, Q. Qian, B.A. Amendt, A.F. Russo and J.C. Murray, 2004. Analysis of Two Translocation Breakpoints and Identification of a Negative Regulatory Element in Patients with Rieger Syndrome. Birth Defects Research (Part A) 70:82-91.
Espinoza, H.M., M. Ganga, U. Vadlamudi, D.M. Martin, B.P. Brooks, J.C. Murray and B.A. Amendt, 2005. Protein Kinase C Phosphorylation Modulates N- and C-terminal Regulatory Activities of the PITX2 Homeodomain Protein. BIOCHEMISTRY, 44:3942-3954.
Vadlamudi, U., H.M. Espinoza, M. Ganga, D.M. Martin, X. Liu, J.F. Engelhardt and B.A.Amendt, 2005. PITX2, -catenin and LEF-1 Interact to Synergistically Regulate the LEF-1 Promoter. J. Cell Sci., 118:1129-1137.
Diamond, E., M. Amen, Q. Hu, H.M. Espinoza, and B.A. Amendt, 2006. Functional Interactions Between Dlx2 and Lymphoid Enhancer Factor Regulate Msx2. Nuc. Acids Res. 34:5951-5965.
Amen, M., X. Liu, U. Vadlamudi, G. Elizondo, E. Diamond , J.F. Engelhardt, and B.A. Amendt, 2007. PITX2 and -catenin Interactions Regulate Lef-1 Isoform Expression. Mol. Cell. Biol. 27:7560-7573.
Ai, D., J. Wang, M-F, Lu, B.A. Amendt, and J.F. Martin, 2007. Nuclear Factor-1 and TCF/LEF recognition elements regulate Pitx2 transcription in pituitary development. Mol. Cell. Biol. 16:5765-5775.
Yin, C., S. R. Venugopalan, M. Akerlund, T. A. Hjalt and B.A. Amendt, 2007. Functional Interactions Between the LIM-Homeodomain Protein Isl-1 and PITX2 Regulate Isl-1 Expression. Submitted, J. Cell Sci.
Shang, Y., T. Yoshida, B.A. Amendt, J. F. Martin and G. K. Owens, 2007. Pitx2 plays a key role in early stages of vascular smooth muscle cell differentiation. Submitted, J. Cell Biol.
Amen, M., H.M. Espinoza, C. Cox, X. Liang, J. Wang, T.M.E. Link, R. G. Brennan, J.F. Martin and B.A. Amendt, 2007. Chromatin-Associated HMG-17 Is a Major Regulator of Homeodomain Transcription Factor Activity Modulated by Wnt/-catenin Signaling. Nuc. Acids Res., doi:10.1093/nar/gkm1047.
Weng, J., X. Cheng, J. Luo, C. Jin, X. Zhou, J. Qu, L. Tu, D. Ai, D. Li, J. Wang, J. F. Martin, B.A. Amendt, and M. Liu, 2007. Deletion of G-protein coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down regulation of Pitx2. Proc. Natl. Acad. Sci., USA, In Press.
Venugopalan, S.R., M.A. Amen, J. Wang, A.C. Cavender, R.N. D'Souza, M. Akerlund, S.L. Brody, T.A. Hjalt, and B.A. Amendt, 2007. Novel Expression and Transcriptional Regulation of FoxJ1 During Orofacial Morphogenesis. Submitted to Hum. Mol. Genet.
Books and/or book chapters published or in press
Wood, P.A., B.A. Amendt, W.J. Rhead, D. Armstrong, D.S. Millington and F. Inoue. 1990. A murine model for short-chain acyl-CoA dehydrogenase deficiency. Fatty acid oxidation: clinical, biochemical and molecular aspects. pp.427-434. Alan N. Liss, Inc.
Amendt, B.A., The Molecular and Biochemical Basis of Axenfeld-Rieger Syndrome, Ch.4 in The Molecular Mechanisms of Axenfeld-Rieger Syndrome. Amendt B.A., ed., Medical Intelligence Unit. Austin: R.G. Landes Co., 2005..
Amendt, B.A., The Role of PITX2 in Tooth Development, Ch.8 in The Molecular Mechanisms of Axenfeld-Rieger Syndrome. Amendt B.A., ed., Medical Intelligence Unit. Austin: R.G. Landes Co., 2005..
Amendt, B.A., Overview of Axenfeld-Rieger Syndrome and the Anterior Segment Developmental Disorders, Ch.10 in The Molecular Mechanisms of Axenfeld-Rieger Syndrome. Amendt B.A., ed., Medical Intelligence Unit. Austin: R.G. Landes Co., 2005.
For other publications, see PubMed (search: